A facile one-pot synthesis of 4-hydroxy-3-methoxycarbonyl-2-methyl-2H-1,2-benzothiazine 1,1-dioxide, a key intermediate in the synthesis of oxicam anti-inflammatory agents

Article abstract of DOI:10.1080/00397919608003652

4-Hydroxy-3-methoxycarbonyl-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (8) was synthesized by a one-pot procedure, starting from the readily available saccharine. The synthesis involves 4 transformations with an overall yield equivalent to that from the stepwise process.

Full text of DOI:10.1080/00397919608003652

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A Facile One-Pot
Synthesis of 4-Hydroxy-3-
methoxycarbonyl-2-
methyl-2H-1,2-
benzothiazine 1,1-Dioxide,
A Key Intermediate in the
Synthesis of Oxicam Anti-
Inflammatory Agents
Norberto Manjarrez a , Herminia I. Pérez a
Aída Solís a & Héctor Luna a
a Departamento Sistemas Biológicos,
,
Universidad Autónoma Metropolitana, Unidad
Xochimilco, P. B. 23–181, México
Published online: 21 Aug 2006.
To cite this article: Norberto Manjarrez , Herminia I. Pérez , Aída Solís & Héctor
Luna (1996) A Facile One-Pot Synthesis of 4-Hydroxy-3-methoxycarbonyl-2-
methyl-2H-1,2-benzothiazine 1,1-Dioxide, A Key Intermediate in the Synthesis of
Oxicam Anti-Inflammatory Agents, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 26:3, 585-591,
DOI: 10.1080/00397919608003652
To link to this article: http://dx.doi.org/10.1080/00397919608003652

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