Chemical and Pharmaceutical Bulletin p. 1039 - 1041 (1995)
Update date:2022-08-11
Topics:
Ishikawa
Kotake
Ishii
Toddacoumaquinone (1), a coumarin-naphthoquinone dimer, was synthesized through Diels-Alder reaction between 8-(1-acetoxy-3-methyl-1,3-butadienyl)-5,7-dimethoxycoumarin (15) and 2-methoxy-1,4-benzoquinone (5). The activities of 1 against several viruses were examined. A weak activity (EC50 = 10 μg/ml) was observed against HSV-1 and HSV-2, but no activity was seen against HIV-1.
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