H. Hamamoto et al. / Tetrahedron Letters 45 (2004) 2293–2295
2295
concentrated in vacuo. Purification of the residue by
column chromatography on silica gel gave the corre-
sponding chroman derivatives (2).
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7
In conclusion, we have developed a novel and direct
synthetic method for chroman derivatives via the cation
radical pathway using hypervalent iodine reagent. The
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15
simplicity of the reaction protocol employing unfunc-
tionalized aromatics in mild reaction systems may find
many advantages for its application to the synthesis of
various types of chroman derivatives. Detailed studies
along these lines are now in progress.
2
Boterff, J.; Verbist, J. F.; Roussakis, C.; Monniot, F. J.
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Acknowledgements
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This work was supported by a Grant-in-Aid for Scien-
tific Research (S) (No 7690) from the Ministry of Edu-
cation, Science, Sports, and Culture, Japan.
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1
2
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