Journal of Asian Natural Products Research p. 418 - 424 (2020)
Update date:2022-08-11
Topics:
Cao, Jun
Shao, Si-Yuan
Zhang, Xu
Yuan, Xiang
Feng, Zi-Ming
Jiang, Jian-Shuang
Yang, Ya-Nan
Zhang, Pei-Cheng
Two new lignans, wikstronoside B (1) and forsysesquinorlignan (2), were isolated from the fruits of Forsythia suspensa, along with two known sesquineolignans, hedyotol A and hedyotol C (3 and 4). The structures of new compounds were established via extensive spectroscopy techniques, including UV, IR, HRESIMS, NMR, and ECD. Compounds 3 and 4 were isolated from this plant for the first time. Their anti-inflammatory effects were evaluated via a detection model with LPS-induced murine macrophage RAW264.7 cells, and compound 3 showed a moderate activity.
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