Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine

Article abstract of DOI:10.3109/00498259509046663

Caffeine N3-demethylation, the major pathway of caffeine metabolism in man, is mediated by P4501A2. The carbon of the methyl group lost during N3-demethylation is eliminated as carbon dioxide in vivo, or as formaldehyde and formic acid in vitro. A simple

Full text of DOI:10.3109/00498259509046663

Xenobiotica
the fate of foreign compounds in biological systems
ISSN: 0049-8254 (Print) 1366-5928 (Online) Journal homepage: http://www.tandfonline.com/loi/ixen20
Determination of P4501A2 activity in human liver
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microsomes using [3- C-methyl]caffeine
J. C. Bloomer, S. E. Clarke & R. J. Chenery
To cite this article: J. C. Bloomer, S. E. Clarke & R. J. Chenery (1995) Determination of P4501A2
14
activity in human liver microsomes using [3- C-methyl]caffeine, Xenobiotica, 25:9, 917-927,
DOI: 10.3109/00498259509046663
To link to this article: http://dx.doi.org/10.3109/00498259509046663
Published online: 22 Sep 2008.
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Date: 30 March 2016, At: 05:32