Enantioselective Catalysis 74. Ligand Excess and Intermediates in the Rhodium-Catalyzed Enantioselective Hydrosilylation of Acetophenone with Pyridineoxazoline Ligands

Article abstract of DOI:10.1016/S0957-4166(00)82204-1

The enantioselective hydrosilylation of acetophenone and diphenylsilane with 2 and the cocatalysts L1 - L4 was investigated.The substitution of hydrogen in the 6-position of the pyridine ring dramatically reduces the dependence of the optical induction on ligand excess, solvent, and concentration of diphenylsilane, acetophenone, and catalyst.The 6-substituents on the pyridine ring are assumed to block one of the coordination sites of rhodium, preventing further interaction with additional ligands, solvents, substrates, and additives.