Tetrahedron Asymmetry p. 4047 - 4057 (1997)
Update date:2022-08-11
Topics:
Ebbers, Eelco J.
Plum, Bart J. M.
Ariaans, Gerry J. A.
Kaptein, Bernard
Broxterman, Quirinus B.
Bruggink, Alle
Zwanenburg, Binne
New resolving bases for ibuprofen 1 and mandelic acid 2 were studied and qualified by their binary phase diagrams of the corresponding salts. It was shown that analysis of the binary phase diagrams gives a good prediction for a resolution process. A comparison of resolving bases revealed that (S)-phenylglycinol (S)-7 is the best resolving base for ibuprofen 1. By the same procedure, various resolving bases for mandelic acid 2 were studied. The known resolving base (S)-MBA 9 was found to be the best for this acid.
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Doi:10.1002/poc.610060806
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