Total synthesis of Resolvin D1, a potent anti-inflammatory lipid mediator

Article abstract of DOI:10.1016/j.tetlet.2012.10.059

The total synthesis of Resolvin D1, a potent endogenous anti-inflammatory lipid mediator derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C7, C8 and C17 were obtained via a chiral pool strategy from 2-deoxy-d-ribose. Witt