
Australian Journal of Chemistry p. 919 - 928 (1995)
Update date:2022-08-11
Topics:
Allan, Robin D.
Apostopoulos, Christine
Hambley, Trevor W.
A synthetic route involving a hydantoin derivative of bicyclo<3.2.0>hept-2-ene has been investigated for the preparation of neurotransmitter analogues containing an additional acetic acid substituent on the cyclobutane ring of the potent NMDA receptor agonist trans-1-aminocyclobutane-1,3-dicarboxylic acid.X-Ray analysis showed that the major cyclobutane amino acid produced had the 2-acetic acid and 3-carboxylic acid substituents in the trans-orientation as a result of epimerization during hydantoin hydrolysis.
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