Agapanthussaponins A-D, new potent cAMP phosphodiesterase inhibitors from the underground parts of Agapanthus inapertus

Article abstract of DOI:10.1248/cpb.41.1784

The saponin fraction prepared from the methanolic extract of the underground parts of Agapanthus inapertus was found to exhibit inhibitory activity on cAMP phosphodiesterase (55.2%) at a concentration of 100 μg/ml. From this fraction, four new steroidal saponins, designated as agapanthussaponin A (1), B (2), C (3) and D (4), were isolated as the active principles, along with an inactive new furostanol saponin (5). The structures of 1-5 were determined by spectroscopic data and hydrolysis. The IC₅₀ of 1- 4 on cAMP phosphodiesterase were 0.7, 1.2, 1.1 and 2.0 (x 10^-5 M), respectively, which are more potent than that of papaverine (IC₅₀ 3.0 x 10^-5 M).

Full text of DOI:10.1248/cpb.41.1784

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service