Catalytic Synthesis of 3-Substituted Indoles using CO as Building Block and Supported Rhodium as Catalyst

Article abstract of DOI:10.1039/c39810000082

Under hydroformylation conditions, using supported rhodium as catalyst, 2-nitrostyrene is directly converted into skatole in ca. 70percent yield, by a reaction involving formation of 2-(o-nitrophenyl)propionaldehyde by homogeneous catalysis, reduction of the nitro-group by heterogeneous catalysis, then ring closure and thermal dehydration.

Full text of DOI:10.1039/c39810000082

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