Synthesis and antibacterial in vitro activity of novel analogues of nematophin

Article abstract of DOI:10.1016/S0960-894X(98)00358-8

The synthesis and in vitro antibacterial activity of new derivatives and analogues of nematophin are described. It was shown that the unsubstituted amide NH-group is essential for bioactivity. Alkyl- or aryl-substitution at the 1-position results in a distinct increase of antibacterial activity. Addition of protein (blood or serum) to the culture media reduces the inhibitory activity on bacteria.