Bioorganic and Medicinal Chemistry Letters p. 2045 - 2050 (1998)
Update date:2022-09-26
Topics:
Himmler, Thomas
Pirro, Franz
Schmeer, Norbert
The synthesis and in vitro antibacterial activity of new derivatives and analogues of nematophin are described. It was shown that the unsubstituted amide NH-group is essential for bioactivity. Alkyl- or aryl-substitution at the 1-position results in a distinct increase of antibacterial activity. Addition of protein (blood or serum) to the culture media reduces the inhibitory activity on bacteria.
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