Tetrahedron Letters p. 7399 - 7402 (1990)
Update date:2022-08-17
Topics:
Pandey, Ravindra K.
Shiau, Fuu-Yau
Medforth, Craig J.
Dougherty, Thomas J.
Smith, Kevin M.
The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo.
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