Use of acetylacetone to prepare a prodrug of cycloserine

DOI: 10.1021/jm00175a002

Source and publish data:

Journal of Medicinal Chemistry p. 6 - 8 (1980)

Update date:2022-08-10

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Authors:

Jensen Jensen

Friedman

Kropp Kropp

Kahan Kahan

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Article abstract of DOI:10.1021/jm00175a002

Several derivatives of cycloserine were prepared and it was found that (R)-4-[(1-methyl-3-oxo-1-butenyl)amino]-3-isoxazolidinone, the condensation product of acetylacetone and cycloserine, was an efficacious prodrug of increased stability under aqueous co

Full text of DOI:10.1021/jm00175a002

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