Preparation of mappicine ketones from camptothecins: Chemistry of the camptothecin E ring

DOI: 10.1016/S0040-4039(00)78177-9

Source and publish data:

Tetrahedron Letters p. 5763 - 5764 (1994)

Update date:2022-08-17

Topics:

Authors:

Fortunak

Mastrocola

Mellinger

Wood Wood

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Article abstract of DOI:10.1016/S0040-4039(00)78177-9

Camptothecin and its analogs are thermolyzed at 150-200 °C to yield mappicine ketone derivatives by loss of carbon dioxide from the α- hydroxylactone.

Full text of DOI:10.1016/S0040-4039(00)78177-9

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