Chemical and Pharmaceutical Bulletin p. 505 - 507 (1998)
Update date:2022-08-11
Topics:
Kitaori, Kazuhiro
Takehira, Yosikazu
Furukawa, Yoshiro
Yoshimoto, Hiroshi
Otera, Junzo
(R)- or (S)-Atenolol (1) in enantiopure form was prepared in an extremely simple way. Atenolol of ca. 95% ee was prepared in one-pot from p- hydroxyphenylacetamide (2) and (R)- or (S)-epichlorohydrin (3). Then, preferential crystallization of the Brensted's acid salts of the resulting atenolol improved the enantiomeric purity up to 99.8% ee.
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