A NOVEL REACTION OF 8,16-BIS(BROMOMETHYL)METACYCLOPHANES WITH PHENYL LITHIUM AND PREPARATION OF 8,16-UNSYMMETRICALLY DISTRIBUTED METACYCLOPHANES

Article abstract of DOI:10.1246/cl.1982.61

The reaction of 8,16-bis(bromomethyl)<2.2>metacyclophanes (2) with phenyl lithium in ethyl ether afforded the unexpected spiro compounds 3.It was also found that 8,16-unsymmetrically disubstituted <2.2>metacyclophanes 9 such as 8-methyl-16-halomethyl- and