Synthesis of new deuterated lipid probes for membrane fluidity measurements

Article abstract of DOI:10.1016/S0009-3084(96)02614-X

New phosphatidylcholine analogs have been synthesized in order to be used as probes for membrane fluidity measurements in ²H-NMR experiments. A 1,3-asymmetrical diether glycerophosphatidylcholine pentadeuterated at the glycerol moiety is elaborated starting from propiolic acid in a 8-steps procedure whereas the corresponding monodeuterated compound is prepared from epibromohydrin.