Chemical Communications p. 6597 - 6600 (2017)
Update date:2022-08-17
Topics:
Ma, Longle
Placzek, Michael S.
Hooker, Jacob M.
Vasdev, Neil
Liang, Steven H.
A copper-mediated 11C-cyanation method employing arylboronic acids and [11C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic 11C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established 11C-cyanation methods that utilize aryl halide precursors.
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