Synthesis and characterization of new aromatic thionitrites

Article abstract of DOI:10.1080/10426509708031580

Thionitrites (S-nitrosothiols) play an essential biological role as nitric oxide (NO^.) carriers. Here, we present the synthesis, the characterization and the stability studies in solution of new aromatic thionitrites 1b-4b as potent nitric oxide donors. The four thionitrites were characterized by ¹H NMR, UV-visible and IR spectroscopies. Their decomposition occurs within a few minutes in dichloromethane, and yields quantitatively the corresponding disulfide. NO^. and the thiyl radicals coming from their decomposition were trapped by distinct spin traps to give characteristic EPR signals. 4b possesses the di-tert-butylphenol moiety responsible for the antioxidant properties of BHT and of the structurally-related drug probucol.

Full text of DOI:10.1080/10426509708031580

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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SYNTHESIS AND CHARACTERIZATION OF
NEW AROMATIC THIONITRITES
a
a
a
Catherine Petit , Pascal Hoffmann , Jean-Pierre Souchard & Serge
a
Labidalle
a
Laboratoire de Synthése, Physico-Chimie et Radiobiologie-JE 175
Université Paul Sabatier - Faculté des Sciences Pharmaceutiques 35 ,
chemin des Mara[icaron]chers, 31062, Toulouse, Cedex 04, France
Published online: 16 Feb 2007.
To cite this article: Catherine Petit , Pascal Hoffmann , Jean-Pierre Souchard & Serge Labidalle (1997)
SYNTHESIS AND CHARACTERIZATION OF NEW AROMATIC THIONITRITES, Phosphorus, Sulfur, and Silicon and
the Related Elements, 129:1, 59-67, DOI: 10.1080/10426509708031580
To link to this article: http://dx.doi.org/10.1080/10426509708031580
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