Et2AlCl promoted coupling reactions of 4-hydroxy-2-pyrone or 4- hydroxycoumarine with aldehydes: Synthesis of methylenebis(4-hydroxy-2- pyrone) or methylenebis(4-hydroxycoumarine) derivatives

Article abstract of DOI:10.3987/COM-98-8429

Methylenebis(4-hydroxy-2-pyrone) or methylenebis(4-hydroxy-coumarine) derivatives (5) have been synthesized from 4-hydroxy-2-pyrones (6) and (8) or 4-hydroxycoumarine (10) with aldehydes (4) in the presence of diethylaluminum chloride.