Organopalladium Approaches to Prostaglandines. 3. Synthesis of Bicyclic and Tricyclic 7-Oxaprostaglandin Endoperoxide Analogues via Oxypalladation of Norbornadiene

Article abstract of DOI:10.1021/jo00186a013

Oxypalladation of norbornadiene provides an organopalladium intermediate 12 readily carbonylated and subsequently elaborated into the first bicyclic and tricyclic 7-oxaprostaglandin endoperoxide analogues 18 and 24 in 22percent and 24percent overall yields, respectively.