Tetrahedron Letters p. 313 - 316 (2010)
Update date:2022-08-16
Topics:
Bramoullé, Yann
Roeda, Dirk
Dollé, Frédéric
A new flow-through system for the production of [11C]phosgene, a versatile labelling agent in radiochemistry for PET, is described. Cyclotron-produced [11C]CH4 is mixed with Cl2 and converted into [11C]CCl4 by passing the mixture through an empty quartz tube at 510 °C. The outflow is directed through a Sb-filled guard that takes out Cl2 and then, without intentional O2 addition, through a second empty quartz tube at 750 °C, giving rise to [11C]phosgene in 30-35% radiochemical yield.
Doi:10.1016/S0040-4020(88)90031-2
(1988)Doi:10.1016/j.jphotochem.2011.02.031
(2011)Doi:10.1039/d1cc00343g
(2021)Doi:10.1021/jacs.1c05276
(2021)Doi:10.1007/s10562-014-1471-6
(2015)Doi:10.1021/acs.jmedchem.9b00517
(2019)
