The Design and Synthesis of ALS Inhibitors from Pharmacophore Models

Article abstract of DOI:10.1016/S0960-894X(99)00301-7

In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.