Stereoselective synthesis of 9-trans-9-desmethyl-9-fluororetinals based on the four-components coupling approach

DOI: 10.1016/S0040-4020(98)01175-2

Source and publish data:

Tetrahedron p. 3675 - 3686 (1999)

Update date:2022-08-10

Topics:

Authors:

Shinada, Tetsuro

Sekiya, Noriko

Bojkova, Nina

Yoshihara, Kazuo

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Article abstract of DOI:10.1016/S0040-4020(98)01175-2

9-trans-9-Desmethyl-9-fluororetinal analogs were synthesized by the four-components coupling approach. Homer-Emmons olefination of 3 afforded the undesired 2E-isomer 5 which was transformed to 6E-triene 8 via the Stille coupling reaction. Isomerization of

Full text of DOI:10.1016/S0040-4020(98)01175-2

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