Stereoselective synthesis of 9-trans-9-desmethyl-9-fluororetinals based on the four-components coupling approach

Article abstract of DOI:10.1016/S0040-4020(98)01175-2

9-trans-9-Desmethyl-9-fluororetinal analogs were synthesized by the four-components coupling approach. Homer-Emmons olefination of 3 afforded the undesired 2E-isomer 5 which was transformed to 6E-triene 8 via the Stille coupling reaction. Isomerization of