Stereoselective synthesis of 9-trans-9-desmethyl-9-fluororetinals based on the four-components coupling approach

DOI: 10.1016/S0040-4020(98)01175-2

Source and publish data:

Tetrahedron p. 3675 - 3686 (1999)

Update date:2022-08-10

Topics:

Authors:

Shinada, Tetsuro

Sekiya, Noriko

Bojkova, Nina

Yoshihara, Kazuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(98)01175-2

9-trans-9-Desmethyl-9-fluororetinal analogs were synthesized by the four-components coupling approach. Homer-Emmons olefination of 3 afforded the undesired 2E-isomer 5 which was transformed to 6E-triene 8 via the Stille coupling reaction. Isomerization of

Full text of DOI:10.1016/S0040-4020(98)01175-2

Products guided by the article

Product name:(2Z,4E,6E)-2-Fluoro-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienoic acid ethyl ester

Cas No:79985-68-5

R&D Labs maybe for 79985-68-5

Shandong Xiangde Biotechnology Co., Ltd

Contact:+86 -15066639877

Address:Sanba street
Tianjin Tongde Biological Technology Co., Ltd.

Contact:86-22-23309138

Address:Room 402, bulidingE3 Detection certification park, XiQingDistrict, Tianjin City
Kunshan Yalong Trading Co,.Ltd

Contact:86-512-57621185

Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China
wuxi leji biology technology co., LTD

website:http://www.lejibio.com/

Contact:18362718864

Address:The Nanyue Road No. 2, Yixing City, Jiangsu Province
ShangHai Ruiyi Medical Technology Co.,Ltd.

Contact:+86-21-54718086

Address:No951 Jianchuan RD，Minhang District

Relevant to this article

Mechanism and structure-reactivity correlation in the homogeneous, unimolecular elimination kinetics of 2-substituted ethyl methylcarbonates in the gas phase

Doi:10.1002/poc.665
(2003)
Doi:10.1021/jo00905a049
(1975)
Doi:10.1007/BF02909760
(1959)
Doi:10.1016/S0020-1693(00)91853-X
(1972)
Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Doi:10.3109/14756366.2015.1096270
(2016)
A NEW CONVERSION OF SILYL ENOL ETHERS INTO THE CORRESPONDING BORON ENOLATES WITH DIALKYLBORON HALIDES OR DIALKYLBORON TRIFLATES, AND CROSS ALDOL REACTIONS VIA THE BORON ENOLATES

Doi:10.1246/cl.1981.153
(1981)

Article Doi