Synthesis of 2-amino-4-chloro-6,9-bis-(2,4-dimethoxybenzyl)-6,7,8,9- tetrahydro-5H-pyrimido[4,5-e][1,4]diazepine: A potentially useful intermediate to pyrimido-[4,5-e][1,4]diazepine-based folates

Article abstract of DOI:10.1515/HC.2004.10.6.405

Reaction of 2-amino-4,6-dichloro-5-chloromethylpyrimidine with N,N′-bis-(2,4-dimethoxybenzyl)-ethane-1,2-diamine gave the title compound 7 which is potentially a useful intermediate to pyrimido[4,5-e][1,4]-diazepine- based folates 1.

Full text of DOI:10.1515/HC.2004.10.6.405

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