European Journal of Medicinal Chemistry p. 765 - 778 (1992)
Update date:2022-08-23
Topics:
Davrinche, C
Nguyen-Tri-Xuong, E
Hamad, Y El
Reynaud, P
Rinjard, P
Tran, G
Amide-oximes and benzodioxanic hydroximates: synthesis of new compounds and neuropsychopharmacological study.The authors describe the ON-(dialkylaminoalkyl) amide-oximes, benzodioxanic hydroximates and also the acetylated derivatives of the former compounds (I) which are detoxified.The hydroximates are obtained without structural ambiguity from thionoesters.Pharmacological testing via the main methods shows that some of these new compounds possess imipraminic, and others neuroleptic properties. benzodioxane/ amide-oxime / hydroximate / antidepressant / neuroleptic /
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