Molecular Structure and Crystal Packing of Monofluoromethoxyarenes

Article abstract of DOI:10.1002/ejoc.201701758

X-ray crystal structures of monofluoromethoxy aryl compounds are presented for the first time. In fluoromethoxybenzene derivatives with at least one unsubstituted ortho-position, the fluoromethoxy group adopts a twisted anisole conformation. The twist is

Full text of DOI:10.1002/ejoc.201701758

Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.
A Journal of
Accepted Article
Title: Molecular Structure and Crystal Packing of
Monofluoromethoxyarenes
Authors: Klaus Müller, Paul Hebeisen, Urs Weiss, André Alker, Bernd
Kuhn, Fang Wang, and Surya Prakash
This manuscript has been accepted after peer review and appears as an
Accepted Article online prior to editing, proofing, and formal publication
of the final Version of Record (VoR). This work is currently citable by
using the Digital Object Identifier (DOI) given below. The VoR will be
published online in Early View as soon as possible and may be different
to this Accepted Article as a result of editing. Readers should obtain
the VoR from the journal website shown below when it is published
to ensure accuracy of information. The authors are responsible for the
content of this Accepted Article.
To be cited as: Eur. J. Org. Chem. 10.1002/ejoc.201701758
Link to VoR: http://dx.doi.org/10.1002/ejoc.201701758
Supported by

Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.
10.1002/ejoc.201701758
European Journal of Organic Chemistry
Molecular Structure and Crystal Packing of Monofluoromethoxyarenes
Paul Hebeisena, Urs Weissa, André Alkera, Bernd Kuhna, Klaus Müllerb,*, Fang Wangc,d G. K.
Surya Prakashc,*,
a
F. Hoffmann-La Roche AG, Pharmaceutical Research & Early Development, Roche
Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland
- Dr. Paul Hebeisen: paul.hebeisen@piqur.com
- Urs Weiss: waltraud.weiss48@gmail.com
- André Alker: andre_m.alker@roche.com
- Dr. Bernd Kuhn: bernd.kuhn@roche.com
b
ETH Zürich, Laboratorium für Organische Chemie, Vladimir-Prelog-Weg 3, 8093 Zürich,
Switzerland
- Prof. (emer.) Dr. Klaus Müller: klaus.mueller@org.chem.ethz.ch
c
Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern
California, Los Angeles, CA 90089-1661, USA
- Dr. Fang Wang: wangfang@mit.edu
- Prof. Dr. Surya Prakash: gprakash@usc.edu
d
Current address: Department of Chemistry, Massachusetts Institute of Technology,
Cambridge, Massachusetts 02139, United States
1
This article is protected by copyright. All rights reserved.

Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.
10.1002/ejoc.201701758
European Journal of Organic Chemistry
* Corresponding Authors:
Prof. (emer.) Klaus Müller
-
Address: Prof. (emer.) Klaus Müller, Laboratory for Organic Chemistry,
ETHZ, CH-8093 Zurich, Switzerland
- Phone: +41 44 632 2890
- Fax: +41 44 632 1328
- E-mail: klaus.mueller@org.chem.ethz.ch
Prof. G. K. Surya Prakash
- Address: Prof. Dr. G. K. Surya Prakash, Loker Hydrocarbon Research Institute and
Department of Chemistry, University of Southern California, Los Angeles, California 90089-
1661
- Phone: +1 213 740 5984
- Fax: +1 213 740 5087
- E-mail: gprakash@usc.edu
2
This article is protected by copyright. All rights reserved.

Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.
10.1002/ejoc.201701758
European Journal of Organic Chemistry
Keywords
monofluoromethoxy group
X-ray crystal structures
conformation
crystal packing
interactions between CF and HC bonds
3
This article is protected by copyright. All rights reserved.