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Glutathione

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Name

Glutathione

EINECS 200-725-4
CAS No. 70-18-8 Density 1.441 g/cm3
PSA 197.62000 LogP -0.72400
Solubility Soluble in water Melting Point 192-195 °C (dec.)(lit.)
Formula C10H17N3O6S Boiling Point 754.492 °C at 760 mmHg
Molecular Weight 307.36 Flash Point 410.102 °C
Transport Information Appearance White cryst. powder
Safety 24/25-36/37/39-27-26 Risk Codes 68-36/37/38
Molecular Structure Molecular Structure of 70-18-8 (Glutathione) Hazard Symbols IrritantXi
Synonyms

Glutathione(8CI);Glycine, N-(N-L-g-glutamyl-L-cysteinyl)-;Copren;Glutathion;Glutathione-SH;Glutide;Glutinal;Isethion;L-Glutathione;N-(N-L-g-Glutamyl-L-cysteinyl)glycine;Tathione;g-Glutamylcysteinylglycine;g-L-Glutamyl-L-cysteinylglycine;Glycine, L-g-glutamyl-L-cysteinyl-;GSH;L-Glutathione Reduced;

 

Glutathione Synthetic route

(3-((S)-5'-oxo-9λ4-boraspiro[bicyclo[3.3.1]nonane-9,2'-[1,3,2]oxazaborolidin]-4'-yl)propanoyl)-L-cysteinylglycine

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 7h;76%
131574-47-5

Boc-Glutathione-OBzl

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With methyl-phenyl-thioether; hydrogen fluoride; 3-methyl-phenol at 0℃; for 1h;62.9%
N-t-butoxycarbonyl-α-t-butyl-L-γ-glutamyl-S-ferrocenylmethyl-L-cysteinylglycine t-butyl ester

N-t-butoxycarbonyl-α-t-butyl-L-γ-glutamyl-S-ferrocenylmethyl-L-cysteinylglycine t-butyl ester

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With thiophenol; trifluoroacetic acid for 3h;52%

methylmercury-L-glutathionate

1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione

A

70-18-8

GLUTATHIONE

mercury sulfide

C

593-74-8

dimethylmercury

D

2033-53-6

1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one

Conditions
ConditionsYield
Stage #1: methylmercury-L-glutathionate; 1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione In water; acetonitrile at 37℃; for 1h;
Stage #2: With sodium hydrogencarbonate In water; acetonitrile at 37℃; for 5h;
A n/a
B 11 mg
C n/a
D 40%

1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione

C17H21HgN3O8S

A

70-18-8

GLUTATHIONE

mercury sulfide

C

bis(4-carboxyphenyl)mercury(II)

D

2033-53-6

1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione; C17H21HgN3O8S In water; acetonitrile at 37℃; for 2h;
Stage #2: With sodium hydrogencarbonate In water; acetonitrile at 37℃;
A n/a
B 12 mg
C n/a
D 32%
27025-41-8

Oxidized glutathione

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
durch elektrolytische Reduktion in saurer Loesung an Quecksilber-Kathoden;
With 4,4'-bipyridinium-1,1'-dipropionate modified glutathione reductase; hydrogen; platinum In water under 760 Torr; Product distribution; Mechanism; Ambient temperature;
With N-Ethylmaleimide; potassium borohydride; ethylenediaminetetraacetic acid at 60℃; for 0.166667h; Product distribution; different disulfides; investigation of reaction conditions;
15401-16-8

N-[S-benzyl-N-(N-benzyloxycarbonyl-L-γ-glutamyl)-L-cysteinyl]-glycine

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With ammonia; sodium
52-90-4

L-Cysteine

56-86-0

L-glutamic acid

56-40-6

glycine

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With liver-substance
636-58-8

N-L-γ-glutamyl-L-cysteine

56-40-6

glycine

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
in Gegenwart von Enzym-Praeparaten aus tierischen Geweben oder aus Mikroorganismen;
With dipotassium hydrogenphosphate; glutathione synthetase; edetate disodium; ATP; sodium hydroxide; magnesium chloride In water for 20h; pH=7.5; Enzymatic reaction;63.5 %Chromat.
With phosphoenolpyruvic acid; adenosine 5'-triphosphate disodium salt hydrate; β-nicotinamideadenine dinucleotide, reduced disodium salt hydrate; glutathione synthetase mutant wild type; type II rabbit muscle lactate dehydrogenase; type II rabbit muscle pyruvate kinase In aq. buffer at 37℃; for 2h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;
56-40-6

glycine

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
in Leber und Leber-Paeparaten;
50410-19-0

(2S)-2-amino-5-((2R)-1-(carboxymethylamino)-3-(1-hydroxy-2-oxopropylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

A

70-18-8

GLUTATHIONE

B

78-98-8

2-oxopropanal

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;
With hyman erythrocyte glyoxalase I In phosphate buffer at 25℃; pH=7.0; Enzyme kinetics; Further Variations:; Catalysts; Hydrolysis;

(2S)-2-amino-5-((2R)-1-(carboxymethylamino)-3-(1-hydroxyethylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

A

70-18-8

GLUTATHIONE

B

75-07-0

acetaldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

(S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1-hydroxy-butylsulfanyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

78-84-2

isobutyraldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

(S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1,2-dihydroxy-ethylsulfanyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

141-46-8

Glycolaldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

(S)-2-Amino-4-[(R)-2-(2-amino-1-hydroxy-ethylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

6542-88-7

aminoacetaldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

(S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1,2,3-trihydroxy-propylsulfanyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

56-82-6

Glyceraldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

(S)-4-[(R)-2-(2-Acetylamino-1-hydroxy-ethylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid

A

70-18-8

GLUTATHIONE

B

64790-08-5

N-acetylaminoacetaldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

(S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(hydroxy-phenyl-methylsulfanyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

100-52-7

benzaldehyde

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

L-γ-glutamyl->S-((Ξ)-1-hydroxy-2-phosphonooxy-ethyl)-L-cysteinyl->glycine

A

870-55-3

phosphoric acid mono-(2-oxo-ethyl) ester

B

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;

L-γ-glutamyl->S-((1Ξ,2Ξ)-1,2-dihydroxy-3-phosphonooxy-propyl)-L-cysteinyl->glycine

A

142-10-9, 591-57-1, 20283-52-7, 591-59-3

DL-glyceraldehyde 3-phosphate

B

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;
108-02-1

captamine

27025-41-8

Oxidized glutathione

A

70-18-8

GLUTATHIONE

B

(S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(2-dimethylamino-ethyldisulfanyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;
108-02-1

captamine

(S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(2-dimethylamino-ethyldisulfanyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

1072-11-3

bis(N,N-dimethyl-2-aminoethyl)disulfide

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;
41656-56-8

(S)-D-lactoylglutathione

A

10326-41-7

D-Lactic acid

B

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With Phorbol 12-myristate 13-acetate; glyoxalase II effect of TPA on enzyme activity;
27025-41-8

Oxidized glutathione

52-90-4

L-Cysteine

A

70-18-8

GLUTATHIONE

B

13081-14-6

N5-((R)-3-(((R)-2-amino-2-carboxyethyl)disulfanyl)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;
With sodium chloride In water-d2 at 25℃; Rate constant; Equilibrium constant; various pD values;
27025-41-8

Oxidized glutathione

6027-13-0

L-homocysteine

A

70-18-8

GLUTATHIONE

B

75027-08-6

(S)-2-Amino-4-[(R)-2-((S)-3-amino-3-carboxy-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;
27025-41-8

Oxidized glutathione

13893-24-8

2-amino-2-methylpropanethiol

A

70-18-8

GLUTATHIONE

B

(S)-2-Amino-4-[(R)-2-(2-amino-2-methyl-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;
52-90-4

L-Cysteine

13081-14-6

N5-((R)-3-(((R)-2-amino-2-carboxyethyl)disulfanyl)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine

A

56-89-3

L-cystine

B

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;
6027-13-0

L-homocysteine

75027-08-6

(S)-2-Amino-4-[(R)-2-((S)-3-amino-3-carboxy-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

B

70-18-8

GLUTATHIONE

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;
52-67-5

3,3-dimethyl-D-cysteine

glutathione disulfide

A

20902-45-8

D-Penicillamin-disulfid

B

70-18-8

GLUTATHIONE

C

92000-26-5

(S)-2-Amino-3-[(R)-2-((R)-4-amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-3-methyl-butyric acid

Conditions
ConditionsYield
Equilibrium constant; Rate constant; pH 7.4;
13893-24-8

2-amino-2-methylpropanethiol

(S)-2-Amino-4-[(R)-2-(2-amino-2-methyl-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

A

70-18-8

GLUTATHIONE

B

4424-49-1

2-(2-Amino-2-methyl-propyldisulfanyl)-1,1-dimethyl-ethylamine

Conditions
ConditionsYield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;
70-18-8

GLUTATHIONE

27025-41-8

Oxidized glutathione

Conditions
ConditionsYield
With bis(4-methoxyphenyl)telluride; rose bengal In water; isopropyl alcohol at 0℃; for 1h; Irradiation;100%
With Cumene hydroperoxide; tert-butyl (S)-(tetrahydrotellurophen-3-yl)carbamate In dichloromethane; water at 25℃; Flow reactor;100%
With imino urea In methanol for 1.83333h; Ambient temperature;99%
70-18-8

GLUTATHIONE

C30H45AsN9O18S3(3-)*3Na(1+)

Conditions
ConditionsYield
With sodium hydroxide; arsenic(III) trioxide In water for 2h;100%
70-18-8

GLUTATHIONE

tri(γ-glutamylcystainylglycinyl)trithioarsenite

Conditions
ConditionsYield
With arsenic(III) trioxide In water for 96h;100%
With arsenic(III) trioxide In water for 96h; N2 atmosphere;86%
70-18-8

GLUTATHIONE

188907-25-7

N-acetyl-S-(2-phenylpropan-3-ol)-L-cysteine

S-(2-phenylpropan-3-ol)-γ-glutathione

Conditions
ConditionsYield
100%
70-18-8

GLUTATHIONE

2-fluorodehydrocoelenterazine

(S)-2-Amino-4-[(R)-2-[[8-benzyl-6-(4-hydroxy-phenyl)-3-oxo-3,7-dihydro-imidazo[1,2-a]pyrazin-2-yl]-(2-fluoro-phenyl)-methylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
In methanol; dichloromethane; water at 20℃; for 3h;100%
70-18-8

GLUTATHIONE

3-fluorodehydrocoelenterazine

(S)-2-Amino-4-[(R)-2-[[8-benzyl-6-(4-hydroxy-phenyl)-3-oxo-3,7-dihydro-imidazo[1,2-a]pyrazin-2-yl]-(3-fluoro-phenyl)-methylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
In methanol; dichloromethane; water at 20℃; for 3h;100%
70-18-8

GLUTATHIONE

4-fluorodehydrocoelenterazine

(S)-2-Amino-4-[(R)-2-[[8-benzyl-6-(4-hydroxy-phenyl)-3-oxo-3,7-dihydro-imidazo[1,2-a]pyrazin-2-yl]-(4-fluoro-phenyl)-methylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
In methanol; dichloromethane; water at 20℃; for 3h;100%
70-18-8

GLUTATHIONE

87-87-6

2,3,5,6-tetrachlorobenzene-1,4-diol

131765-87-2

(S-glutathionyl)-TriCH

Conditions
ConditionsYield
With PcpC-C14S glutathione transferase; ascorbic acid at 30 - 65℃; for 0.333333h; pH=6.5; aq. phosphate buffer; Enzymatic reaction;100%
70-18-8

GLUTATHIONE

1196873-32-1

diethyl [1-methyl-1-([4-(iodoacetamido)benzylidene]azinoyl)ethyl]phosphonate

1196873-33-2

C26H40N5O11PS

Conditions
ConditionsYield
at 25℃; pH=7.4; aq. phosphate buffer; Darkness;100%
70-18-8

GLUTATHIONE

C20H30N2O7

1374677-38-9

C30H47N5O13S

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃;100%
70-18-8

GLUTATHIONE

1217898-39-9

{[2 (ferrocenylmethoxy)ethyl]sulfonyl}ethene

C25H33FeN3O9S2

Conditions
ConditionsYield
With sodium tetrahydroborate In water; N,N-dimethyl-formamide at 20℃; for 1h;100%
70-18-8

GLUTATHIONE

1202757-89-8

N-(3-{5-fluoro-2-[4-(2-methoxy-ethoxy)-phenylamino]-pyrimidin-4-ylamino}-phenyl)-acrylamide

(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(3-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenylamino)-3-oxopropylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane at 0 - 20℃; for 16h;100%
821-09-0

n-Pent-4-enyl alcohol

70-18-8

GLUTATHIONE

1497404-41-7

C15H27N3O7S

Conditions
ConditionsYield
With 2,2’-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride In water for 3h; UV-irradiation;100%
70-18-8

GLUTATHIONE

1233858-76-8

4-(5-phenyl-3-(selenocyanatomethyl)-1H-pyrazol-1-yl)benzenesulfonamide

2-amino-4-{1-(carboxymethyl-carbamoyl)-2-[5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3yl]methylselanylthiol-ethylcarbamoyl}-butyric acid

Conditions
ConditionsYield
In tetrahydrofuran; water Alkaline conditions;100%
70-18-8

GLUTATHIONE

144-48-9

iodacetamide

glutathione

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 1h; pH=8.2;100%
In aq. buffer at 37℃; for 0.5h; Darkness;
98026-79-0

3-bromo-1H-pyrrole-2,5-dione

70-18-8

GLUTATHIONE

Glu-Cys(Mal)-Gly

Conditions
ConditionsYield
In methanol for 0.0833333h;100%
70-18-8

GLUTATHIONE

C29H45NO12S2

C32H54N4O16S2

Conditions
ConditionsYield
for 24h; pH=8;100%
70-18-8

GLUTATHIONE

342807-90-3

3,5-bis(2-hydroxybenzylidene)tetrahydro-4H-pyran-4-one

C39H50N6O16S2

Conditions
ConditionsYield
In water; acetonitrile for 2h; Reflux;100%
70-18-8

GLUTATHIONE

3-((1’-(2”-acetamido-2”-deoxy-β-D-glucopyranosyl)-[1’,2’,3’]-triazo-4’-yl)methyloxy)-1-propene

S-(3’-((1’’-(2”’-acetamido-2”’-deoxy-β-D-glucopyranosyl)[1’’,2’’,3’’]-triazo-4’’-yl)methyloxy)-1’-propyl)-γ-L-glutamyl-L-cysteinylglycine

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In aq. acetate buffer for 4h; pH=4; Irradiation;100%
70-18-8

GLUTATHIONE

26555-40-8

Methoxycarbonylsulfenyl chloride

C12H19N3O8S2

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; Inert atmosphere;100%
70-18-8

GLUTATHIONE

bis(4-(dimethylamino)phenyl)methylium tetrafluoroborate

C27H37N5O6S*BF4(1-)*H(1+)

Conditions
ConditionsYield
In water; acetonitrile at 20℃;100%
70-18-8

GLUTATHIONE

1378277-97-4

C42H48N3O2(1+)

1378277-98-5

C52H65N6O8S(1+)

Conditions
ConditionsYield
at 37℃; for 0.166667h; pH=7.4; aq. phosphate buffer;99.3%
70-18-8

GLUTATHIONE

73230-64-5

2-desoxy-2-C-methylene-D-threo-pentono-1,4-lactone

73230-74-7

2-Amino-4-[1-(carboxymethyl-carbamoyl)-2-((4R,5R)-4-hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furan-3-ylmethylsulfanyl)-ethylcarbamoyl]-butyric acid

Conditions
ConditionsYield
In water at 25℃; for 1h;99%
70-18-8

GLUTATHIONE

16305-88-7

Norophthalamic acid

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; triethyl phosphite In aq. phosphate buffer; acetonitrile at 20℃; for 2h; pH=7; Catalytic behavior; Solvent; Reagent/catalyst; pH-value; Irradiation;99%
With triethyl borane; triethyl phosphite 1.) CH3CN, H2O, RT, 2 min, 2.) CH3CN, H2O, RT, irradiation, 8 h; Multistep reaction;
With tris(2,2'-bipyridyl)ruthenium dichloride; trisodium tris(3-sulfophenyl)phosphine; 2-methylpropan-2-thiol In aq. phosphate buffer at 20℃; for 5h; pH=7.4; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Irradiation;87 %Spectr.
UV-irradiation;
With di-tert-butyl peroxide; trisodium tris(3-sulfophenyl)phosphine In aq. phosphate buffer at 20℃; for 6h; pH=7; UV-irradiation;
70-18-8

GLUTATHIONE

107-02-8

acrolein

124521-13-7

S-(3-oxopropyl)glutathione

Conditions
ConditionsYield
In water at 20℃; for 1h; Addition;99%
With phosphate buffer; ethylenediaminetetraacetic acid In water at 25℃; Kinetics; Addition; Michael addition;
In ethanol; water at 37℃; for 2h; pH=8; aq. phosphate buffer;
70-18-8

GLUTATHIONE

100-14-1

4-nitrobenzyl chloride

6803-19-6

S-(p-nitrobenzyl)-glutathione

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;99%
70-18-8

GLUTATHIONE

110637-58-6

Alloc-Lys-OH TFA salt

C20H35N5O10S*C2HF3O2

Conditions
ConditionsYield
With tris(2,2′-bipyrazine-N1,N1′)ruthenium(II) hexafluorophosphate In water for 2h; Concentration; Irradiation;99%
70-18-8

GLUTATHIONE

1-(5-chloropent-1-ynyl)-1,2-benziodoxol-3(1H)-one

S-glutathione-(5-chloropent-1-ynyl)-1,2-vinylbenziodoxolone

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 0.0833333h; pH=8.2; stereoselective reaction;99%
70-18-8

GLUTATHIONE

57564-91-7

S-Nitrosoglutathione

Conditions
ConditionsYield
With diethylenetriaminopentaacetic acid; L-phenylalanine; 1-nitrosopyrrolidine-2-thiocarboxamide at 37℃; pH=1.5; Reagent/catalyst; Darkness;98%
With hydrogenchloride; diethylenetriaminopentaacetic acid; 3-nitroso-1,3-thiazolidine-4-thiocarboxamide In aq. phosphate buffer; acetonitrile at 37℃; pH=1.5; Kinetics; Reagent/catalyst; Darkness;95%
With hydrogenchloride; sodium nitrite In water at 5℃; for 0.666667h; Inert atmosphere;77%
70-18-8

GLUTATHIONE

177960-06-4

(1H-benzo[d][1,2,3]triazol-1-yl)(naphthalen-2-yl)methanone

(S)-5-((R)-3-(2-naphthoylthio)-1-(carboxymethylamino)-1-oxopropan-2-ylamino)-2-amino-5-oxopentanoic acid

Conditions
ConditionsYield
With potassium hydrogencarbonate In methanol; water at 20℃;98%

Glutathione Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Glutathione Specification

Glutathione (CAS NO.70-18-8), its Synonyms are Glycine, N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine ; Copren ; Deltathione ; Glutide ; Glutinal ; Glutathione ; gamma-L-Glutamylcysteinylglycine ; Glycine, L-gamma-glutamyl-L-cysteinyl- . It is white powder. Glutathione (GSH) is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.

Physical properties about Glutathione are: (1)ACD/LogP: -1.645; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -5.12; (4)ACD/LogD (pH 7.4): -5.15; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00 ; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 9; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 11; (12)Index of Refraction: 1.572; (13)Molar Refractivity: 70.105 cm3; (14)Molar Volume: 213.204 cm3; (15)Polarizability: 27.792 10-24cm3; (16)Surface Tension: 69.3659973144531 dyne/cm; (17)Density: 1.441 g/cm3; (18)Flash Point: 410.102 °C; (19)Enthalpy of Vaporization: 119.618 kJ/mol; (20)Boiling Point: 754.492 °C at 760 mmHg

Uses of Glutathione: Glutathione (CAS NO.70-18-8) is a biological and chemical reagents, detoxification drugs which is mainly used for poisoning such as heavy metals, acrylonitrile, fluoride, carbon monoxide and organic solvents. Glutathione can also decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP.

When you are using this chemical, please be cautious about it as the following:
1.Avoid contact with skin and eyes;
2.Wear suitable protective clothing, gloves and eye/face protection;
3.Take off immediately all contaminated clothing;
4.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1;
(2)InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N;
(3)SmilesN[C@@H](CCC(=O)N[C@H](C(=O)NCC(=O)O)CS)C(=O)O;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 4gm/kg (4000mg/kg)   "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968Vol. -, Pg. 97, 1968.
mouse LD50 intraperitoneal 4020mg/kg (4020mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse LD50 intravenous 2238mg/kg (2238mg/kg)   Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
 
mouse LD50 oral 5gm/kg (5000mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse LD50 subcutaneous 5gm/kg (5000mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
rabbit LD50 intravenous > 2gm/kg (2000mg/kg)   Biochemical Journal. Vol. 41, Pg. 325, 1947.

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