2,2,2-TRIFLUOROETHYL METHYL ETHER

Base Information

• Chemical Name: 2,2,2-TRIFLUOROETHYL METHYL ETHER
• CAS No.: 460-43-5
• Molecular Formula: C3H5 F3 O
• Molecular Weight: 114.067
• Hs Code.: 2909199090
• Mol file: 460-43-5.mol

Synonyms:Ether,methyl 2,2,2-trifluoroethyl (6CI,8CI); 1,1,1-Trifluoro-2-methoxyethane;2,2,2-Trifluoroethyl methyl ether; R-E 143a

Chemical Property of 2,2,2-TRIFLUOROETHYL METHYL ETHER

Chemical Property:

• Melting Point: -16°C
• Refractive Index: 1.2942
• Boiling Point: 7.4 °C at 760 mmHg
• Flash Point: 30°C
• PSA: 9.23000
• Density: 1.131 g/cm³
• LogP: 1.19510

Purity/Quality:

99% ^*data from raw suppliers

2,2,2-TrifluoroethylMethylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s): FXi
• Hazard Codes: F,Xi
• Statements: 12
• Safety Statements: 16-23-29-33

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-TRIFLUOROETHYL METHYL ETHER

There total 14 articles about 2,2,2-TRIFLUOROETHYL METHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

2,2,2-Trifluoroethyl p-toluenesulfonate (433-06-7) + sodium methylate (124-41-4) → 2,2,2-trifluoroethyl methyl ether (460-43-5)

Guidance literature:

In methanol; at 20 ℃; for 4h;

Reference yield: 55.0%

methanol (67-56-1) + 1,1,1-trifluoro-2-chloroethane (75-88-7) → 1,1,1,2-tetrafluoroethane (811-97-2) + 2,2,2-trifluoroethyl methyl ether (460-43-5) + 1-Chloro-2,2-difluoroethene (359-10-4)

Guidance literature:

With potassium hydroxide; at 260 ℃; for 10h; under 57760 Torr;

DOI:10.1016/S0022-1139(01)00469-9

Reference yield: 50.0%

Aluminum Tri-(2,2,2-trifluoroethoxide) (17655-83-3) + methyl iodide (74-88-4) → 2,2,2-trifluoroethyl methyl ether (460-43-5)

Guidance literature:

In N,N-dimethyl-formamide; at 59 - 70 ℃; for 48h;

upstream raw materials:

diazomethane

2,2,2-trifluoroethanol

methanol

2,2,2-trifluorodiazoethane

Downstream raw materials:

methyl p-toluene sulfonate

Carbonyl fluoride

Methyl formate

2,2,2-trifluoroethyl formate

Refernces

• 1、 -. "Method for preparing hydrofluoroether through two-step process". Paragraph 0055; 0057. . Retrieved 2019/07/10.
• 2、 Chen, Xin,Brauman, John I.. "Hydrogen bonding lowers intrinsic nucleophilicity of solvated nucleophiles". scheme or table. p. 15038 - 15046. Retrieved 2009/03/12.