Ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate

Base Information

Chemical Name:Ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate
CAS No.:78852-50-3
Molecular Formula:C9H10ClN3O2S
Molecular Weight:259.71
Hs Code.:
Mol file:78852-50-3.mol

Synonyms:ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate;Carbamic acid, [[(5-chloro-2-pyridinyl)amino]thioxomethyl]-, ethyl ester (9CI)

Suppliers and Price of Ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl N-{[(5-chloro-2-pyridinyl)amino]carbothioyl}carbamate
500mg
$ 393.00

Matrix Scientific
Ethyl N-{[(5-chloro-2-pyridinyl)amino]carbothioyl}carbamate
5g
$ 3136.00

Matrix Scientific
Ethyl N-{[(5-chloro-2-pyridinyl)amino]carbothioyl}carbamate
1g
$ 785.00

Chemcia Scientific
Ethyl[(5-chloro-2-pyridinyl)amino]carbothioylcarbamate ＞97%
5 G
$ 600.00

Chemcia Scientific
Ethyl[(5-chloro-2-pyridinyl)amino]carbothioylcarbamate ＞97%
0.5 G
$ 140.00

Total 5 raw suppliers

Chemical Property of Ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate

Chemical Property:

PKA:6.20±0.70(Predicted)
PSA：105.87000
Density:1.435±0.06 g/cm3(Predicted)
LogP:2.60280

Purity/Quality:

99% ^*data from raw suppliers

Ethyl N-{[(5-chloro-2-pyridinyl)amino]carbothioyl}carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate

There total 1 articles about Ethyl [(5-chloro-2-pyridinyl)amino]carbothioylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 78852-50-3
ethyl [(5-chloropyridin-2-yl)carbamothioyl]carbamate

Guidance literature:: In 1,4-dioxane; at 20 ℃; for 14h;

Reference yield:

: 78852-50-3
ethyl [(5-chloropyridin-2-yl)carbamothioyl]carbamate

: 1443763-60-7
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 2 h / 60 °C

2.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene / 18 h / Inert atmosphere; Reflux

3.1: potassium phosphate; potassium fluoride / toluene / 0.25 h / 20 °C / Inert atmosphere

3.2: 3 h / 85 °C / Inert atmosphere

With potassium fluoride; potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; XPhos; In methanol; ethanol; toluene;

Reference yield:

: 78852-50-3
ethyl [(5-chloropyridin-2-yl)carbamothioyl]carbamate

: 1443763-71-0
(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 2 h / 60 °C

2: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene; 1-methyl-pyrrolidin-2-one / 2 h / Inert atmosphere; Reflux

3: dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate / toluene; 1-methyl-pyrrolidin-2-one / 2 h / Inert atmosphere; Reflux

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate; dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; XPhos; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; toluene;