Bioorganic and Medicinal Chemistry Letters p. 3598 - 3602 (2016)
Update date:2022-08-03
Topics: Chemical Synthesis Toxicity Assessment Formulation Development Regulatory Approval Analytical Characterization Pharmacokinetics and Pharmacodynamics Preclinical and Clinical Testing Data Analysis and Publication Water Solubility Testing Efficacy Evaluation
Feng, Siliang
Chen, Kuncheng
Wang, Chenhong
Jiang, Xifeng
Dong, Huajin
Gong, Zehui
Liu, Keliang
Novel water-soluble paclitaxel prodrugs were designed and synthesized by introducing morpholino groups through different linkers. These derivatives showed 400–20,000-times greater water solubility than paclitaxel as well as comparable activity in MCF-7 an
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Doi:10.1016/S0040-4020(98)00985-5
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