Start by conducting a comprehensive literature review to understand the structural features and mechanisms of action of nimesulide and related COX inhibitors. Determine the specific pharmacological properties you want to enhance or modify in the pyridine analogues.
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4-nitro-3-(3-bromophenylamino)pyridine N-oxide
(E)-2-(4-fluorostyryl)-3,4,5-trimethoxybenzaldehyde
diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate
Silica gel
