Design the tetrahydro-β-carboline derivatives with the goal of achieving sub-nanomolar selectivity for gelatinases. This involves structure-activity relationship (SAR) studies to predict which structural modifications might improve inhibitory activity.
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(1RS)-2-(4''-methoxy-4'-phenoxybenzenesulfonyl)-1,2,3,4-tetrahydro-norarmano-1-carboxylic acid
4-fluoro-2-(methoxycarbonylmethyl)benzenesulfonamide
4-nitro-3-(3-bromophenylamino)pyridine N-oxide
N-(4-BroMo-phenyl)-benzene-1,2-diaMine
2,3-dibromo-1-(bromomethyl)-4,5-dimethoxybenzene
ETHYL 3,5-DIAMINOBENZOATE
tert-butyl 4-(4-cyanobenzylcarbamoyl)piperidine-1-carboxylate
C106H105N5O14S2
hexyl bis[(R)-2-(4-benzyloxyphenyloxy)propionate]
C29H32N4O6
4′-(1-methylbenzo[f]quinolin-3-yl)-N,N-diphenyl[1,1′-biphenyl]-4-amine
4-Bromobenzaldehyde
Cyclohexanone
7-(N-(2-methoxyphenylamino)methyl)-(20S)-camptothecin
Methyl 5-{2-[2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-3-(methoxycarbonyl)benzoate
methyl 4-[(4-nitrophenyl)methoxy]benzenepropanoate
