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| CAS No.: | 100-43-6 |
|---|---|
| Name: | 4-Vinylpyridine |
| Article Data: | 43 |
| Molecular Structure: | |
|
|
|
| Formula: | C7H7N |
| Molecular Weight: | 105.139 |
| Synonyms: | Pyridine,4-vinyl- (8CI);2-(4-Pyridyl)ethylene;4-Ethenylpyridine;NSC18256;g-Vinylpyridine;Pyridine, 4-ethenyl-; |
| EINECS: | 202-852-0 |
| Density: | 0.968 g/cm3 |
| Melting Point: | < 25oC |
| Boiling Point: | 173.627 °C at 760 mmHg |
| Flash Point: | 51.667 °C |
| Solubility: | 29 g /L (20 °C) in water |
| Appearance: | dark brown to yellow liquid |
| Hazard Symbols: |
 T
|
| Risk Codes: | 10-25-34-42/43-23/25 |
| Safety: | 23-26-36/37/39-45-28A-16 |
| Transport Information: | UN 3073 6.1/PG 2 |
| PSA: | 12.89000 |
| LogP: | 1.72460 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
| Conditions | Yield |
|---|---|
| With C25H39P; tetrabutyl ammonium fluoride; palladium diacetate In tetrahydrofuran at 25℃; for 24h; Hiyama Coupling; Schlenk technique; Inert atmosphere; | 99% |
| Conditions | Yield |
|---|---|
| With methoxy(cyclooctadiene)rhodium(I) dimer; N,N-Dimethylacrylamide; 3-Methoxybenzoic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 90℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; chemoselective reaction; | 85% |
- 5344-27-4
4-(2-hydroxyethyl)pyridine
- 648894-30-8
methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate
A
- 100-43-6
4-vinylpyridine
| Conditions | Yield |
|---|---|
| With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 10℃; | A n/a B 84% |
| Conditions | Yield |
|---|---|
| With C17H36ClN6NiP2(1+)*Cl(1-); potassium tert-butylate In toluene at 120℃; for 16h; Suzuki-Miyaura Coupling; Inert atmosphere; | 84% |
- 181219-01-2
4-pyridineboronic acid pinacol ester
- 100-43-6
4-vinylpyridine
| Conditions | Yield |
|---|---|
| Stage #1: 4-pyridineboronic acid pinacol ester; vinylmagnesium halide In tetrahydrofuran at -78 - 20℃; for 2.25h; Inert atmosphere; Stage #2: With trifluoroacetyl chloride In tetrahydrofuran at -78 - -40℃; for 18.5h; Inert atmosphere; Further stages; | 76% |
| Conditions | Yield |
|---|---|
| With trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate In 1,4-dioxane; water at 100℃; Inert atmosphere; | 55.55% |
- 108-89-4
picoline
- 67-56-1
methanol
A
- 100-43-6
4-vinylpyridine
B
- 536-75-4
4-Ethylpyridine
C
- 108-47-4
2,4-lutidine
| Conditions | Yield |
|---|---|
| Cs exchanged zeolite at 450℃; Product distribution; investigation of the heterogeneous vapor-phase alkylation of γ-picoline with methanol over Na+, K+, Rb+, or Cs+ exchanged X- or Y-type zeolite in an atmosphere of nitrogen; | A 3.7% B 27.1% C 13.8% |
- 34064-35-2
4-(oxiran-2-yl)pyridine
- 100-43-6
4-vinylpyridine
| Conditions | Yield |
|---|---|
| With potassium thioacyanate In ethanol; water for 46h; Ambient temperature; | 5% |
| Conditions | Yield |
|---|---|
| With water; hydrogen at 215℃; anschl. mit NaOH und 2-Amino-phenol unter vermindertem Druck auf Siedetemperatur; | |
| With water at 275℃; beim Leiten ueber mit Zinkfluorid impraegniertes Al2O3; | |
| Cs-ZSM-5 at 200 - 400℃; for 4 - 8h; |
| Conditions | Yield |
|---|---|
| With potassium hydroxide unter Ausschluss von Licht und anschl. Erwaermen unter 12 Torr auf Siedetemperatur; | |
| With potassium hydroxide at 175℃; under 30 Torr; |
- 32718-18-62,4-Imidazolidinedione,1-bromo-3-chloro-5,5-dimethyl-
- 3978-81-24-tert-Butylpyridine
- 10396-10-8p-Toluenesulfonyl semicarbazide
- 11141-17-61H,7H-Naphtho[1,8-bc:4,4a-c']difuran-5,10a(8H)-dicarboxylicacid,10-(acetyloxy)octahydro-3,5-dihydroxy-4-methyl-8-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]o
- 1907-33-1Lithium tert-butoxide
- 2231-57-4Thiocarbohydrazide
- 2425-79-81,4-Butane diglycidyl ether
- 2189-60-81-Phenyloctane
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- Total:23 Page 1 of 1 1
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Consensus Reports
Reported in EPA TSCA Inventory.
Specification
The 4-Vinylpyridine, with the CAS registry number 108-10-1,is also known as gamma-Vinylpyridine. It belongs to the product categories of Vinyl Halides, Amines, Amides, and Other Vinyl Monomers. Its EINECS number is 202-852-0. This chemical's molecular formula is C7H7N and molecular weight is 105.14. What's more,Its systematic name is 4-Vinylpyridine.It is a dark brown to yellow liquid which is stable,incompatible with strong acids,strong oxidizing agents.It is a reagent for blocking cysteine function in proteins.4-Vinylpyridine can be used as organic intermediate and pharmaceutical intermediate. It can also be used as monomer in the manufacturing of polymer.
Physical properties about 4-Vinylpyridine are:
(1)ACD/LogP: 1.824; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.58; (4)ACD/LogD (pH 7.4): 1.82; (5)ACD/BCF (pH 5.5): 8.08; (6)ACD/BCF (pH 7.4): 14.18; (7)ACD/KOC (pH 5.5): 131.94; (8)ACD/KOC (pH 7.4): 231.65; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.563; (13)Molar Refractivity: 35.268 cm3; (14)Molar Volume: 108.605 cm3; (15)Polarizability: 13.981 10-24cm3 ; (16)Surface Tension: 36.1959991455078 dyne/cm; (17)Density: 0.968 g/cm3; (18)Flash Point: 51.667 °C; (19)Enthalpy of Vaporization: 39.315 kJ/mol; (20)Boiling Point: 173.627 °C at 760 mmHg; (21)Vapour Pressure: 1.67900002002716 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:C=Cc1ccncc1;
(2)Std. InChI:InChI=1S/C7H7N/c1-2-7-3-5-8-6-4-7/h2-6H,1H2;
(3)Std. InChIKey:KFDVPJUYSDEJTH-UHFFFAOYSA-N.
Safety Information of 4-Vinylpyridine:
The 4-Vinylpyridine is flammable and causes burns ,so keep away from sources of ignition - No smoking .And it may cause sensitization by inhalation and skin contact ,so do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .When you use it ,wear suitable protective clothing, gloves and eye/face protection .In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ,and in case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
The toxicity data of 4-Vinylpyridine are as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 100mg/kg (100mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
| guinea pig | LD50 | oral | 321mg/kg (321mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984. |
| guinea pig | LDLo | skin | 500mg/kg (500mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 845, 1986. | |
| mammal (species unspecified) | LD50 | oral | 216mg/kg (216mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. | |
| mouse | LC50 | inhalation | 380mg/m3/2H (380mg/m3) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984. |
| mouse | LD50 | oral | 161mg/kg (161mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984. |
| rat | LC50 | inhalation | 170mg/m3 (170mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(9-10), Pg. 64, 1992. | |
| rat | LD50 | oral | 100mg/kg (100mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 845, 1986. |