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| CAS No.: | 107-31-3 |
|---|---|
| Name: | Methyl formate |
| Article Data: | 567 |
| Molecular Structure: | |
|
|
|
| Formula: | C2H4O2 |
| Molecular Weight: | 60.0526 |
| Synonyms: | Methanoicacid methyl ester;Methyl methanoate;Formiate de methyle;Methylformiaat;Methylformiat; |
| EINECS: | 203-481-7 |
| Density: | 0.92 g/cm3 |
| Melting Point: | -100 °C |
| Boiling Point: | 26 °C at 760 mmHg |
| Flash Point: | ?16°F |
| Solubility: | 300 g/L (20 °C) |
| Appearance: | colourless liquid |
| Hazard Symbols: |
 F+, Xn
|
| Risk Codes: | 12-20/22-36/37 |
| Safety: | 9-16-24-26-33 |
| Transport Information: | UN 1243 3/PG 1 |
| PSA: | 26.30000 |
| LogP: | 0.42510 |
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- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
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| Conditions | Yield |
|---|---|
| With titanium(IV) fluoride In chloroform-d1; dichloromethane at 24.84℃; for 48h; | |
| With calcined hydrogen type ferrierite base having a silica-alumina ratio is 10: 1 at 150℃; under 15001.5 Torr; Reagent/catalyst; Temperature; Pressure; Inert atmosphere; | |
| With MCC-22 at 90℃; under 750.075 Torr; Temperature; Pressure; Reagent/catalyst; Autoclave; Industrial scale; | |
| With H-type MCM-22 In water at 90℃; under 750.075 Torr; Reagent/catalyst; Temperature; Pressure; |
- 201230-82-2
carbon monoxide
A
- 67-56-1
methanol
B
- 64-17-5
ethanol
C
- 107-31-3
Methyl formate
D
- 107-21-1
ethylene glycol
| Conditions | Yield |
|---|---|
| With hydrogen In various solvent(s) at 300℃; under 1471020 Torr; Further byproducts given; | |
| With hydrogen; dicobalt octacarbonyl; dodecacarbonyl-triangulo-triruthenium; tris(1-methylethyl)phosphine In toluene at 270℃; under 1520000 Torr; for 1h; Yield given. Yields of byproduct given; | |
| With 2-hydroxypyridin; hydrogen; acetylacetonatodicarbonylrhodium(l) In various solvent(s) at 230℃; under 1499480 Torr; for 4.5h; Further byproducts given. Title compound not separated from byproducts; | A 284 mmol B 191 mmol C 52 mmol D 1000 mmol |
| With 1-(pyridine-2-yl)ethanol; hydrogen; acetylacetonatodicarbonylrhodium(l) In various solvent(s) at 230℃; under 1499480 Torr; for 4.5h; Further byproducts given. Title compound not separated from byproducts; | A 284 mmol B 191 mmol C 52 mmol D 1000 mmol |
| With hydrogen; dodecacarbonyltetrarhodium(0) In tetrahydrofuran at 230℃; under 1800 Torr; for 1h; Yield given. Further byproducts given. Yields of byproduct given; |
| Conditions | Yield |
|---|---|
| With Cu/Al2O3; dihydrogen peroxide In chloroform at 50℃; for 24h; Reagent/catalyst; Solvent; | 84% |
| Conditions | Yield |
|---|---|
| With sulfuric acid In water for 4h; Reflux; | 80% |
| With (triphenylphosphine)gold(I) chloride; oxygen; silver(I) triflimide In dichloromethane-d2 at 25℃; for 12h; | 55% |
| Conditions | Yield |
|---|---|
| With hydrogen In N,N-dimethyl-formamide at 160℃; under 30003 Torr; for 8h; Inert atmosphere; Autoclave; |
- 67-56-1
methanol
- 201230-82-2
carbon monoxide
A
- 50-00-0
formaldehyd
B
- 107-31-3
Methyl formate
C
- 124-38-9
carbon dioxide
| Conditions | Yield |
|---|---|
| With hydrogen In N,N-dimethyl-formamide at 160℃; under 30003 Torr; for 8h; Inert atmosphere; Autoclave; |
| Conditions | Yield |
|---|---|
| Stage #1: carbon dioxide With phenylsilane In N,N-dimethyl acetamide at 50℃; under 22502.3 Torr; for 4h; pH=Ca. 1.2; Autoclave; Stage #2: methanol In N,N-dimethyl acetamide Pressure; Temperature; Reagent/catalyst; | 100% |
| With hydrogen; HCO2Ru3(CO)10 at 125℃; under 12928.7 Torr; for 24h; Product distribution; other catalysts, various reaction conditions; | |
| With hydrogen; HCO2Ru3(CO)10 at 125℃; under 12928.7 Torr; for 24h; Yield given; |
| Conditions | Yield |
|---|---|
| With ammonium chloride; lithium hexamethyldisilazane In tetrahydrofuran; ethyl acetate | 91% |
- 115-10-6
Dimethyl ether
- 201230-82-2
carbon monoxide
A
- 67-56-1
methanol
B
- 107-31-3
Methyl formate
C
- 79-20-9
acetic acid methyl ester
D
- 64-19-7
acetic acid
| Conditions | Yield |
|---|---|
| With 25 wt.percent Heteropoly acids supported on SBA-15 In ethanol at 200℃; under 11251.1 Torr; for 1.5h; |
| Conditions | Yield |
|---|---|
| With oxygen In water at 20℃; Reagent/catalyst; Irradiation; | 16% |
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- 7758-09-0Potassium nitrite
- 3965-55-71,3-Benzenedicarboxylicacid, 5-sulfo-, 1,3-dimethyl ester, sodium salt (1:1)
- 68515-73-1D-Glucopyranose,oligomeric, decyl octyl glycosides
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
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- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- Total:27 Page 1 of 1 1
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Chemistry
Molecular Structure of Methyl formate (CAS NO.107-31-3):
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IUPAC Name: methyl formate
CAS No.: 107-31-3
EINECS: 203-481-7
Molecular Formula: C2H4O2
Molecular Weight: 60.05 g/mol
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 26.3 Å2
Index of Refraction: 1.328
Molar Refractivity: 13.24 cm3
Molar Volume: 65.2 cm3
Surface Tension: 21.3 dyne/cm
Enthalpy of Vaporization: 27.92 kJ/mol
Vapour Pressure: 732 mmHg at 25°C
Melting Point: -100 °C
Density: 0.92 g/cm3
Boiling Point: 26 °C at 760 mmHg
Product Categories: Refrigerants; Organics; Analytical Chemistry; Solvents for HPLC & Spectrophotometry; Solvents for Spectrophotometry; Fatty Acid Methyl Esters (GC Standard); Standard Materials for GC
The chemical synonymous: Formiate de methyle ; Formiatedemethyle ; Formiatedemethyle(French) ; Hcooch3 ; Methyl ester of formic acid ; Methyle(formiatede) ; Methyle(formiatede)(French) ; Methylester Kyseliny Mravenci
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | skin | > 20mL/kg (20mL/kg) | National Technical Information Service. Vol. OTS0556689, | |
| mouse | LD50 | oral | 675mg/kg (675mg/kg) | National Technical Information Service. Vol. OTS0556689, | |
| rabbit | LD50 | oral | 1622mg/kg (1622mg/kg) | Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972. | |
| rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | National Technical Information Service. Vol. OTS0556797, | |
| rat | LC50 | inhalation | 5200mg/m3/4H (5200mg/m3) | National Technical Information Service. Vol. OTS0556791, | |
| rat | LD50 | oral | 475mg/kg (475mg/kg) | National Technical Information Service. Vol. OTS0556689, | |
| rat | LD50 | skin | > 4gm/kg (4000mg/kg) | National Technical Information Service. Vol. OTS0556791, |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Moderately toxic by ingestion. Inhalation of vapor can cause irritation to nasal passages and conjunctiva, optic neuritis, narcosis, retching, and death from pulmonary irritation. Industrial fatalities have occurred only with exposure to high concentrations. Flammable liquid. Very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. Reacts with methanol + sodium methoxide to form an explosive product. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
F+; 
Xn
Risk Statements:
R12 Extremely flammable.
R20/22 Harmful by inhalation and if swallowed.
R36/37 Irritating to eyes and respiratory system.
Safety Statements:
S9 Keep container in a well-ventilated place.
S16 Keep away from sources of ignition - No smoking.
S24 Avoid contact with skin.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S33 Take precautionary measures against static discharges.
Standards and Recommendations
OSHA PEL: TWA 100 ppm; STEL 150 ppm
ACGIH TLV: TWA 100 ppm; STEL 150 ppm
DFG MAK: 50 ppm (120 mg/m3)
DOT Classification: 3; Label: Flammable Liquid
Specification
Methyl formate (CAS NO.107-31-3) is the methyl ester of formic acid. The simplest example of an ester, it is a clear liquid with an ethereal odor, high vapor pressure and low surface tension.In the laboratory, it can be produced by the condensation reaction of methanol and formic acid, as follows:
HCOOH + CH3OH → HCOOCH3 + H2O
Industrial Methyl formate , however, is usually produced by the combination of methanol and carbon monoxide (carbonylation) in the presence of a strong base, such as sodium methoxide:
CH3OH + CO → HCOOCH3
It is used primarily to manufacture formamide, dimethylformamide, and formic acid. Because of its high vapor pressure, it is used for quick-drying finishes. It is also used as an insecticide and to manufacture certain pharmaceuticals. Under the trademark Ecomate, it is now used a a blowing agent for foam insulation, as a replacement for CFC, HCFC, or HFCs, with zero ozone depletion potential and zero global warming potential.