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110-67-8

Basic Information
CAS No.: 110-67-8
Name: 3-Methoxypropionitrile
Article Data: 38
Molecular Structure:
Molecular Structure of 110-67-8 (3-Methoxypropionitrile)
Formula: C4H7NO
Molecular Weight: 85.1057
Synonyms: NSC61486;b-Methoxypropionitrile;3-Methoxy propionitrile;Propionitrile,3-methoxy- (6CI,7CI,8CI);1-Cyano-2-methoxyethane;1-Methoxy-2-cyanoethane;2-Cyanoethyl methyl ether;Methyl b-cyanoethyl ether;NSC 4090;
EINECS: 203-790-7
Density: 0.902 g/cm3
Melting Point: -62.9 °C
Boiling Point: 163 °C at 760 mmHg
Flash Point: 61.1 °C
Solubility: 335 g/L (20 °C) in water
Appearance: colourless liquid
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36-37/39
PSA: 33.02000
LogP: 0.54648
Synthetic route
67-56-1

methanol

107-13-1

acrylonitrile

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
With [μN,κP,κC,κN-{2-(i-Pr2PO),6-(CH2NBn)-(C6H3)}Ni]2 In benzene at 50℃; for 1h;100%
With 1-Methylpyrrolidine; barium(II) hydroxide In methanol at 25℃; for 7h;98%
86%
124-41-4

sodium methylate

107-13-1

acrylonitrile

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
In methanol; water at 45℃; for 3h; Temperature;93%
67-56-1

methanol

50434-02-1

2-cyanoethyl nitrate

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
With sodium hydroxide In water at 9 - 11℃; for 1h; Etherification;83%
67-56-1

methanol

107-13-1

acrylonitrile

A

151-18-8

2-cyanoethylamine

B

110-67-8

3-Methoxypropionitrile

C

107-12-0

propiononitrile

Conditions
ConditionsYield
With ammonia; hydrogen; chromium; cobalt; iron; nickel at 100℃; under 60004.8 Torr;A 65%
B 20%
C 15%
109-78-4

3-Hydroxypropionitrile

110-67-8

3-Methoxypropionitrile

15438-67-2

(3-methoxypropyl)amide

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
With phosphorus pentoxide
67-56-1

methanol

124-41-4

sodium methylate

107-13-1

acrylonitrile

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
at 20℃; Rate constant;
at 20℃; Kinetics;
107-31-3

Methyl formate

109-78-4

3-Hydroxypropionitrile

A

110-67-8

3-Methoxypropionitrile

B

2141-62-0

3-(ethoxy)propionitrile

Conditions
ConditionsYield
With diethyl ether; sodium ethanolate
109-78-4

3-Hydroxypropionitrile

616-38-6

carbonic acid dimethyl ester

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
With sodium methylate; benzene
96-34-4

methyl chloroacetate

107-13-1

acrylonitrile

110-67-8

3-Methoxypropionitrile

Conditions
ConditionsYield
With sodium amalgam; water
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    Product Name: 3-Methoxypropionitrile CAS: 110-67-8 MF: C4H7NO MW: 85.1 EINECS: 203-790-7 Mol File: 110-67-8.mol 3-Methoxypropionitrile Structure 3-Methoxypropionitrile Chemical Properties Melting point -62.9 °C Boiling poi

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Chemistry

Product Name: 3-Methoxypropionitrile  (CAS NO.110-67-8)

Molecular formula: C4H7NO
Molecular Weight: 85.1
EINECS: 203-790-7
Boiling Point: 163 °C at 760 mmHg
Flash Point: 61.1 °C
Index of Refraction: 1.387 
Molar Refractivity: 22.23 cm
Molar Volume: 94.3 cm3 
Surface Tension: 29.2 dyne/cm 
Density: 0.902 g/cm
Enthalpy of Vaporization: 39.95 kJ/mol  
Vapour Pressure: 2.11 mmHg at 25°C 
Refractive index: n20/D 1.403(lit.)
Water Solubility: 335 g/L (20 °C)
BRN: 1739284
IUPAC Name: 3-methoxypropanenitrile
Product Categories: C1 to C5;Cyanides/Nitriles; Nitrogen Compounds
Synonyms: 2-Cyanoethyl methyl ether ; 1-Cyano-2-methoxyethane ; 2-cyanoethylmethylether ; 3-methoxy-propionitril ; 3-Methoxypropylnitrile ; 3-methoxy-propanenitril ; 3-Methoxypropanenitrile ; 3-Methoxypropannitril

Uses

 3-Methoxypropionitrile  (CAS NO.110-67-8) is used in organic synthesis, but also a good solvent for plastic polymers.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2900mg/kg (2900mg/kg)   Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 19, Pg. 225, 1969.
mouse LD50 oral 3200mg/kg (3200mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 916, 1986.
rabbit LD50 skin > 10mL/kg (10mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LD50 oral 4390mg/kg (4390mg/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Consensus Reports

Reported in EPA TSCA Inventory. Cyanide and its compounds are on the Community Right-To-Know List.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Flammable liquid when exposed to heat, flame, or oxidizers. Reacts with water, steam, or acids to produce toxic and flammable vapors. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of CN. See also NITRILES.
Safety Information of 3-Methoxypropionitrile  (CAS NO.110-67-8):
The Hazard Codes:  Xi
HazardClass: 3.2
The Risk Statements information:
36/37/38:  Irritating to eyes, respiratory system and skin 
Safety Statements information:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 
37/39:  Wear suitable gloves and eye/face protection  
RIDADR: 3276
WGK Germany: 2
RTECS: TZ4870000
PackingGroup: III
HS Code: 29269095