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| CAS No.: | 127-00-4 |
|---|---|
| Name: | 1 -Chloro-2-propanol |
| Article Data: | 109 |
| Molecular Structure: | |
|
|
|
| Formula: | C3H7ClO |
| Molecular Weight: | 94.541 |
| Synonyms: | 1-Chloro-2-hydroxypropane;1-Chloroisopropyl alcohol;NSC77373;sec-Propylene chlorohydrin;a-Propylene chlorohydrin; |
| EINECS: | 204-819-6 |
| Density: | 1.083 g/cm3 |
| Boiling Point: | 126.499 °C at 760 mmHg |
| Flash Point: | 54.541 °C |
| Appearance: | colourless to light yellow liquid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 10-20-36/37/38 |
| Safety: | 26-36/39 |
| Transport Information: | UN 2611 6.1/PG 2 |
| PSA: | 20.23000 |
| LogP: | 0.60600 |
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- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 75-56-9, 16033-71-9
methyloxirane
- 127-00-4
1-Chloro-2-propanol
| Conditions | Yield |
|---|---|
| With chloro-trimethyl-silane; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 1h; ring opening reaction; | 97% |
| With chloro-trimethyl-silane; zinc(II) oxide In dichloromethane at 20℃; for 0.5h; regioselective reaction; | 85% |
| With chlorine |
- 75-56-9, 16033-71-9
methyloxirane
A
- 78-89-7
2-chloro-1-propanol
B
- 107-18-6
allyl alcohol
C
- 127-00-4
1-Chloro-2-propanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride In solid at 60 - 70℃; for 7h; in tri-o-thymotide clathrate; | A 5% B 87% C 8% |
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate Reduction; | 85% |
| With tris(pentafluorophenyl)borate; hydrogen In diethyl ether at 70℃; under 45603.1 Torr; for 12h; Solvent; Glovebox; | 85% |
| Stage #1: chloroacetone With sodium tetrahydroborate In ethanol at 20℃; Cooling with ice; Stage #2: With hydrogenchloride In ethanol; water | 50% |
| Conditions | Yield |
|---|---|
| With chlorourea; acetic acid | A n/a B 80% |
| With hypochloric acid | |
| With sulfuric acid; chloroamine-T In water; acetone at 50℃; Yield given. Yields of byproduct given; |
| Conditions | Yield |
|---|---|
| With morpholine-borane; boron trifluoride diethyl etherate In diethyl ether for 2h; Product distribution; Ambient temperature; | 80% |
| With Bu3Sn(tripiperidinophosphine oxide)I; tri-n-butyl-tin hydride In tetrahydrofuran at 60℃; for 1h; | 77% |
| With ethanol; nickel Hydrogenation.unter Druck; |
- 88504-84-1
2-hydroxypropyl perchlorate
- 127-00-4
1-Chloro-2-propanol
| Conditions | Yield |
|---|---|
| With lithium chloride In tetrachloromethane; acetone for 1h; | 80% |
| Conditions | Yield |
|---|---|
| With ammonium cerium(IV) nitrate; tri-n-butyl benzyl ammonium chloride In acetonitrile for 3h; Ambient temperature; | A 70% B 18% |
| With hydrogenchloride | |
| With pyridine hydrochloride In chloroform for 1h; Ambient temperature; | A 18 % Chromat. B 68 % Chromat. |
| Stage #1: methyloxirane With chromyl chloride In dichloromethane at -50℃; for 2h; Ring cleavage; Stage #2: With water In dichloromethane at -50 - 20℃; Hydrolysis; |
- 67-56-1
methanol
- 75-56-9, 16033-71-9
methyloxirane
A
- 107-98-2
1-methoxy-2-propanol
B
- 1589-47-5
2-methoxypropanol
C
- 127-00-4
1-Chloro-2-propanol
| Conditions | Yield |
|---|---|
| With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 25℃; | A 56% B 40% C 4% |
| With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 60℃; | A 49% B 47% C 4% |
- 187737-37-7
propene
A
- 623-60-9
1-chloro-2-acetoxypropane
C
- 70-55-3
toluene-4-sulfonamide
D
- 127-00-4
1-Chloro-2-propanol
| Conditions | Yield |
|---|---|
| With chloroamine-T; acetic acid at 50 - 60℃; for 3h; | A 43% B 17% C n/a D 10% E n/a |
- 187737-37-7
propene
- 64-19-7
acetic acid
A
- 623-60-9
1-chloro-2-acetoxypropane
C
- 70-55-3
toluene-4-sulfonamide
D
- 127-00-4
1-Chloro-2-propanol
| Conditions | Yield |
|---|---|
| With chloroamine-T at 50 - 60℃; for 3h; | A 43% B 17% C n/a D 10% E n/a |
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Chemistry
Chemical Name: 1-Chloro-2-propanol
IUPAC NAME: 1-Chloropropan-2-ol ; (2S)-1-chloropropan-2-ol ; (2R)-1-chloropropan-2-ol
CAS No.: 127-00-4
EINECS: 204-819-6
RTECS: UA8942000
Molecular Formula: C3H7ClO
Molecular Weight: 94.54 g/mol
Density: 1.082 g/cm3
Flash Point: 54.5 °C
Boiling Point: 126.5 °C at 760 mmHg
Following is the structure of 1-Chloro-2-propanol (CAS No.127-00-4):
Product Categories about 1-Chloro-2-propanol (CAS No.127-00-4) is refer to Organics
The chemical synonymous of 1-Chloro-2-propanol (CAS No.127-00-4) are (±)-1-Chloro-Propan-2-Ol ; 1-Chloro-2-Hydroxypropane ; 1-Chloro-2-Propano ; 1-Chloro-2-Propanol(Sec-Propylenechlorohydrin) ; 1-Chloroisopropyl Alcohol ; 1-Chloroisopropylalcohol ; 1-Chloro-Iso-Propylalcohol,1-Propylenechloro-Hydrin ; 2-Propanol,1-Chloro-
Uses
1-Chloro-2-propanol (CAS No.127-00-4) is used as an organic synthesis intermediates,and it mainly used in the manufacture of propylene oxide and propylene glycol.
Toxicity Data With Reference
| 1. | mmo-sat 40 µmol/plate | FCTXAV Food and Cosmetics Toxicology. 18 (1980),115. | ||
| 2. | mma-sat 1100 µg/plate | MUREAV Mutation Research. 30 (1975),303. | ||
| 3. | ihl-rat LC50:1000 ppm/4H | 85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,517. |
Safety Profile
Low toxicity by inhalation. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl−. See also individual components.
Hazard Codes: 
Xn
Risk Statements about 1-Chloro-2-propanol (CAS No.127-00-4):
R10:Flammable.
R20:Harmful by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements about 1-Chloro-2-propanol (CAS No.127-00-4):
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Attention:
1. Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container.
2. Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Standards and Recommendations
ACGIH TLV: TWA 1 ppm (skin); Not Classifiable as a Human Carcinogen