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| CAS No.: | 420-04-2 |
|---|---|
| Name: | Cyanamide |
| Article Data: | 297 |
| Molecular Structure: | |
|
|
|
| Formula: | CH2N2 |
| Molecular Weight: | 42.0403 |
| Synonyms: | Alzogur;Amidocyanogen;Carbamonitrile;Carbimide;Cyanoamine;Cyanogen nitride;Cyanogenamide;Deurbraak;Dormex;Hydrogen cyanamide;N-Cyanoamine;NSC 24133;TsAKS; |
| EINECS: | 206-992-3 |
| Density: | 0.998 g/cm3 |
| Melting Point: | 45-46 °C(lit.) |
| Boiling Point: | 258.5 °C at 760 mmHg |
| Flash Point: | 1.2 °C |
| Solubility: | 775 g/L in water |
| Appearance: | white crystalline solid |
| Hazard Symbols: |
|
| Risk Codes: | 21-25-36/38-43 |
| Safety: | 3-22-36/37-45 |
| Transport Information: | UN 2811 6.1/PG 3 |
| PSA: | 49.81000 |
| LogP: | 0.12648 |
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- 17356-08-0
thiourea
- 420-04-2
CYANAMID
| Conditions | Yield |
|---|---|
| With copper(ll) sulfate pentahydrate; triethylamine In dimethyl sulfoxide at 20℃; for 1h; Reagent/catalyst; Solvent; | 100% |
| With mercury(II) oxide | |
| With lead(II) hydroxide on calcium carbonate |
- 55986-20-4
N-(p-tolylsulfonyl)dibenzylselenimide
- 17356-08-0
thiourea
A
- 420-04-2
CYANAMID
B
- 1842-38-2
dibenzyl selenide
C
- 70-55-3
toluene-4-sulfonamide
| Conditions | Yield |
|---|---|
| In methanol for 0.5h; Mechanism; Ambient temperature; | A 72% B 98% C 98% |
- 71150-48-6
N-phenylsulfonyl-Te,Te-diphenyltellurimide
A
- 98-10-2
benzenesulfonamide
B
- 420-04-2
CYANAMID
C
- 1202-36-4
diphenyl telluride
| Conditions | Yield |
|---|---|
| With thiourea In acetonitrile Ambient temperature; | A 95% B 74% C 97% |
- 62486-35-5
Te,Te-di(p-methoxyphenyl)-N-(p-tolylsulfonyl)tellurimide
A
- 420-04-2
CYANAMID
B
- 4456-34-2
bis(4-methoxyphenyl)telluride
C
- 70-55-3
toluene-4-sulfonamide
| Conditions | Yield |
|---|---|
| With thiourea In acetonitrile Ambient temperature; | A 75% B 95% C 90% |
| Conditions | Yield |
|---|---|
| With carbon dioxide 40°C; | 92% |
| With sulfuric acid | |
| With nitric acid |
- 71150-49-7, 140925-80-0, 140925-81-1
N-(trichloroacetyl)-di-(p-methoxyphenyl)tellurimide monohydrate
A
- 420-04-2
CYANAMID
B
- 594-65-0
trichloroacetamide
C
- 4456-34-2
bis(4-methoxyphenyl)telluride
| Conditions | Yield |
|---|---|
| With thiourea In acetonitrile Ambient temperature; | A 72% B 90% C 92% |
| Conditions | Yield |
|---|---|
| With carbon dioxide In methanol 40°C, 3 h; filtration, evapn. of solvent at 11 Torr; | 90% |
| With carbon dioxide In not given byproducts: CaCO3; leading of CO2, filtration of CaCO3, acidifying with acetic acid to pH=6; evapn. at 40°C and 10-20 Torr, cooling down to ambient temp., after concentration cooling down to 5-10°C, drying in vac.; dissolving in ether, filtration, evapn. of ether or pptn. with benzene, distillation at 85-87°C and 0.5 Torr; | |
| With carbon dioxide byproducts: CaCO3; 30-32°C; |
| Conditions | Yield |
|---|---|
| With dinitrogen trioxide; sulfuric acid In not given cold soln. of guanidine in dild. H2SO4; | 70% |
| With H2SO4; N2O3 In not given cold soln. of guanidine in dild. H2SO4; | 70% |
| With cis-nitrous acid |
- 55051-36-0
N-(diisopropoxyphosphinothioyl)thiourea
- 786-50-5
10-chloroacetylphenothiazine
A
- 92-84-2
10H-phenothiazine
B
- 420-04-2
CYANAMID
C
- 126588-17-8
[4-Oxo-thiazolidin-(2Z)-ylidene]-thiophosphoramidic acid O,O'-diisopropyl ester
D
- 126588-21-4
10-<<(diisopropoxyphosphinothioyl)thio>acetyl>phenothiazine
| Conditions | Yield |
|---|---|
| With triethylamine In benzene 1) 80 deg C, 1.5 h, 2) 3 d room temp.; | A n/a B n/a C n/a D 53% |
- 75-75-2
methanesulfonic acid
- 59579-33-8
bis(trimethylgermyl)carbodiimide
A
- 420-04-2
CYANAMID
B
- 79463-94-8
trimethylgermyl methylsulfonate
| Conditions | Yield |
|---|---|
| In neat (no solvent) Ge-compound distilled into a vessel held at -196°C containing organic compound, mixture reacted at room temp. for 10 min; filtered in N2, volatiles removed in vac.; | A n/a B 50% |
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Chemistry
The Molecular Structure of Cyanamide (CAS NO.420-04-2):
Empirical Formula: CH2N2
Molecular Weight: 42.04
IUPAC Name: cyanamide
Appearance: white crystalline solid
Nominal Mass: 42 Da
Average Mass: 42.04 Da
Monoisotopic Mass: 42.021798 Da
Index of Refraction: 1.396
Molar Refractivity: 10.13 cm3
Molar Volume: 42.1 cm3
Surface Tension: 45.3 dyne/cm
Density: 0.998 g/cm3
Flash Point: 1.2 °C
Enthalpy of Vaporization: 49.61 kJ/mol
Boiling Point: 258.5 °C at 760 mmHg
Vapour Pressure: 0.0137 mmHg at 25°C
Storage temp: 2-8°C
Water Solubility: 775 g/L
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates;Inorganics;C1 to C5;Cyanides/Nitriles;Nitrogen Compounds
Stability: Unstable - heat sensitive. Incompatible with strong oxidizing agents, strong reducing agents, bases, acids, iron and its salts, steel, brass, lead, moisture. Reacts with acids to produce very toxic gas
InChI
InChI=1/CH2N2/c2-1-3/h2H2
Smiles
C(N)#N
Synonyms: MeSH Heading ; Cyanamide [JAN] ; 4-03-00-00145 (Beilstein Handbook Reference) ; Alzogur ; Amidocyanogen ; BRN 1732569 ; Carbamonitrile ; Carbimide ; Caswell No. 485A ; Cyanoamine ; Cyanogen nitride ; Cyanogenamide ; Deurbraak ; Dormex ; EINECS 206-992-3 ; EPA Pesticide Chemical Code 014002 ; HSDB 1550 ; Hydrogen cyanamide ; N-Cyanoamine ; UNII-21CP7826LC
Uses
Cyanamide (CAS NO.420-04-2) is used as industrial raw materials, pharmaceutical, pesticide intermediates, agricultural fertilizers, plant regulators and food additives, etc.
Production
Cyanamide (420-04-2) is produced by hydrolysis of calcium cyanamide, which in turn is prepared from calcium carbide via the Frank-Caro process. The main reaction exhibited by cyanamide involves additions of protic reagents. Water, hydrogen sulfide , and hydrogen selenide add to give urea, thiourea, and selenourea, respectively.
Toxicity Data With Reference
| 1. | orl-rat LD50:125 mg/kg | MEIEDD Merck Index. 10 (1983),383. | ||
| 2. | ihl-rat LCLo:86 mg/m3/4H | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,40. | ||
| 3. | skn-rat LD50:84 mg/kg | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,40. | ||
| 4. | ipr-rat LDLo:200 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 54 (1943),254. | ||
| 5. | ipr-mus LD50:200 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 . | ||
| 6. | skn-rbt LD50:590 mg/kg | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,190. |
Consensus Reports
Cyanamide (420-04-2) is reported in EPA TSCA Inventory. Cyanide and its compounds are on the Community Right-To-Know List.
Safety Profile
Hazard Codes: 
T
Risk Statements: 21-25-36/38-43
R21: Harmful in contact with skin.
R25: Toxic if swallowed.
R36/38: Irritating to eyes and skin.
R43: May cause sensitization by skin contact.
Safety Statements: 3-22-36/37-45
S3: Keep in a cool place.
S22: Do not breathe dust.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 2
RTECS: GS5950000
HazardClass: 8
PackingGroup: III
Poison by ingestion, inhalation, and intraperitoneal routes. Moderately toxic by skin contact. Experimental reproductive effects. Combustible when exposed to heat or flame. .
Standards and Recommendations
OSHA PEL: TWA 2 mg/m3
ACGIH TLV: TWA 2 mg/m3
Specification
1、Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
2、Handling and Storage
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4°C/39°F.)