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| CAS No.: | 113-00-8 |
|---|---|
| Name: | Aminomethanamidine |
| Molecular Structure: | |
|
|
|
| Formula: | CH5 N3 |
| Molecular Weight: | 59.0708 |
| Synonyms: | Aminoformamidine;Aminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Imidourea; Iminourea |
| Density: | 1.55g/cm3 |
| Boiling Point: | 132.9°Cat760mmHg |
| Flash Point: | 34.2°C |
| Safety: | Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. On heating to 160° it converts to melamine and NH3. Keep well closed. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 75.89000 |
| LogP: | 0.33890 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
| Conditions | Yield |
|---|---|
| With diisopropyl-carbodiimide | 100% |
| With dicyclohexyl-carbodiimide | 99.7% |
| Conditions | Yield |
|---|---|
| With dicyclohexyl-carbodiimide | 99% |
| With diisopropyl-carbodiimide | 96.7% |
| Conditions | Yield |
|---|---|
| With C36H44N12Sn4 at 60℃; for 0.5h; Temperature; Time; Inert atmosphere; Schlenk technique; | 98.9% |
| Conditions | Yield |
|---|---|
| 180-200°C; 30 min; | 88% |
| Conditions | Yield |
|---|---|
| 180-200°C; 30 min; | 87% |
| Conditions | Yield |
|---|---|
| 180-200°C; 30 min; | 83% |
- 10581-07-4
N-cyclohexyl-N',N'-pentamethylenediylurea
- 13360-63-9
N-ethylbutylamine
- 113-00-8
guanidine nitrate
| Conditions | Yield |
|---|---|
| With trichlorophosphate In water; toluene | 81% |
| Conditions | Yield |
|---|---|
| With sulfur dioxide at molar ratio of urea:SO2:NH3 = 1:3:7; 245-265°C; in autoclave; | 80% |
| With aluminum(III) sulfate; ammonium chloride In ammonia High Pressure; 300°C; 30 min; urea : NH4Cl : Al2(SO4)3 = 1:1:0.33; 140 atm; | 72% |
| With aluminum(III) sulfate; ammonium chloride In ammonia High Pressure; 300°C; 30 min; urea : NH4Cl : Al2(SO4)3 = 1:1:0.33; 70 atm; | 68% |
- 420-04-2
CYANAMID
- 1484-26-0
3-(benzyloxy)aniline
A
- 113-00-8
guanidine nitrate
B
- 205935-12-2
N-(3-Benzyloxy-phenyl)-guanidine
| Conditions | Yield |
|---|---|
| In water | A n/a B 80% |
- 124-46-9, 20734-13-8, 100224-74-6, 593-85-1
guanidine hydrogen carbonate
- 113-00-8
guanidine nitrate
| Conditions | Yield |
|---|---|
| With ammonia; potassium at 50℃; for 72h; Autoclave; | 78% |
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Chemistry
Structure of Guanidine (CAS NO.113-00-8):
Molecular Formula: CH5N3
Molar mass: 59.07 g/mol
EINECS: 204-021-8
Density: 1.55 g/cm3
Flash Point: 34.2 °C
Index of Refraction: 1.595
Boiling Point: 132.9 °C at 760 mmHg
Vapour Pressure: 8.67 mmHg at 25°C
Appearance: Colorless crystals
Solubility: Easily soluble in water and alcohol
Product categories: Pharmaceutical Intermediates
XLogP3-AA: -1.3
H-Bond Donor: 3
H-Bond Acceptor: 3
IUPAC Name: Guanidine
Canonical SMILES: C(=N)(N)N
InChI: InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)
InChIKey: ZRALSGWEFCBTJO-UHFFFAOYSA-N
Uses
Guanidine (CAS NO.113-00-8) is used in the manufacture of plastics and explosives and as intermediate in organic synthesis. Is mainly used for manufacture of sulfa drugs and dyes. Because of free guanidine difficult to be separated, so general merchandise is its salts, such as Guanidine hydrochloride , Guanidine nitrate , Guanidine carbonate , Guanidine sulfate .
Production
Guanidine (CAS NO.113-00-8) can be pbtained from the role of Calcium and Ammonium iodide or the reaction of Urea and Ammonia under pressurized.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| frog | LDLo | subcutaneous | 3gm/kg (3000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. | |
| mouse | LD50 | intraperitoneal | 350mg/kg (350mg/kg) | Bulletin of Experimental Biology and Medicine Vol. 61, Pg. 291, 1966. | |
| mouse | LDLo | subcutaneous | 266mg/kg (266mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. | |
| rabbit | LDLo | oral | 500mg/kg (500mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 718, 1989. | |
| rat | LDLo | subcutaneous | 150mg/kg (150mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. |
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. On heating to 160° it converts to melamine and NH3. Keep well closed. When heated to decomposition it emits toxic fumes of NOx.
Specification
Guanidine (CAS NO.113-00-8) is a crystalline compound of strong alkalinity, and also can be called Carbamamidine ; Iminourea ; Guanidinium sulfate ; Bisguanidinium sulfate and Aminoformamidine . There is deliquescence, and it is easy to absorb carbon dioxide from the air tobe strongly alkaline. When heated to 160 °C, it will be decomposed into Melamine and Ammonia .