104420-79-3

Upstream product

• 67-56-1 methanol 
• 7138-34-3 p-chloromandelic acid 
• 4998-15-6 4-chlorophenylglyoxal 
• 37542-28-2 methyl (p-chlorphenyl)glyoxylate 
• 60-29-7 diethyl ether 
• 7732-18-5 water 
• 492-86-4 (R)-4-chloro-α-hydroxy-benzeneacetic acid 
• 13312-83-9 4-chloromandelonitrile 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 1353044-28-6 (4-chlorophenyl)[dimethyl(phenyl)silyl]methanol 
• 1504663-21-1 [4-chlorophenyl(dimethylphenylsilyl)methoxy]trimethylsilane 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 37542-28-2 methyl (p-chlorphenyl)glyoxylate 
• 18584-27-5 2-(4-chlorophenyl)-2-hydroxyacetamide 
• 492-86-4 (R)-4-chloro-α-hydroxy-benzeneacetic acid 
• 63096-36-6 (4-chloro-phenyl)-hydroxy-acetic acid methyl ester 
• 24091-92-7 methyl 2-bromo-2-(4-chlorophenyl)acetate 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 1260146-56-2 1-hydroxy-1-(4-chlorophenyl)-3-phenylpropanone 
• 1260146-94-8 C₁₆H₂₆ClNO₃Si 
• 854676-79-2 1-hydroxy-1-(4-chlorophenyl)-3-phenylpropanone 
• 1260146-93-7 2-(4-chlorophenyl)-2-hydroxy-N-methoxy-N-methylacetamide 
• 1584127-67-2 (S)-(+)-methyl 2-acetoxy-2-(4-chlorophenyl)acetate 
• 32174-34-8 (4-chloro-phenyl)-hydroxy-acetic acid methyl ester 
• 4674-24-2 2-(4-chlorophenyl)-2-methoxyacetic acid 
• 114898-40-7 methyl 2-(acetylthio)-2-(4-chlorophenyl)acetate 

Relevant academic research and scientific papers

Facile synthesis of aryl α-keto esters via the reaction of aryl diazoacetate with H2O and DEAD

A facile synthesis of aryl aα-keto esters in high yields is reported involving the reaction of aryl diazoacetate with H2O and diethyl azodicarboxylate (DEAD) catalyzed by dirhodium acetate. Georg Thieme Verlag Stuttgart.

Direct Aerobic α-Hydroxylation of Arylacetates for the Synthesis of Mandelates

Aerobic α-hydroxylation of α-methylene esters has proven challenging due to overoxidation and hydrolysis of the materials. In this article, KOtBu-promoted TBAB-catalyzed α-hydroxylation of α-methylene aryl esters using O2as the oxyge

Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source

A Co-catalyzed effective transfer hydrogenation of various α-ketoesters and N-cyclicsulfonylimides by safe and environmentally benign H2O as hydrogen source is described. The reaction used easily available and easy to handle zinc metal as a reductant. Interestingly, the catalytic system does not require ligand for reduction of N-cyclicsulfonylimides. (Figure presented.).

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.

A containing "1, 3, 4 - oxadiazole thioether" mandelic acid derivatives and use thereof

The invention discloses a containing "1, 3, 4 - oxadiazole thioether" mandelic acid derivatives and their use in the application of the fungi anti-plants sickness, the compound has the general formula (B) structure shown: In the formula, R1 Is H, methyl, fluorine or chlorine, R2 C for containing1 - 3 Straight-chain alkyl, containing C1 - 4 Branched alkyl, propenyl, propynyl or mono-substituted benzyl, wherein the single substituted benzyl substituent is "nitro, methyl, trifluoromethyl, methoxy, three methoxy, fluorine, and bromine". The invention to replace the mandelic acid as the skeleton, mandelic acid introduced in the structure of the "oxadiazole thioether" structure, design synthesizing a containing "1, 3, 4 - oxadiazole thioether" structure of the mandelic acid derivatives, anti-plant disease fungal activity tests show that the class of compounds of plant diseases caused by fungi has good inhibition activity, for the new pesticide research and development and create provide important scientific basis.

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Ru-MACHO-Catalyzed Highly Chemoselective Hydrogenation of α-Keto Esters to 1,2-Diols or α-Hydroxy Esters

A ruthenium pincer catalyst has been shown to be highly effective for the hydrogenation of a wide range of α-keto esters, affording either diols or hydroxy esters depending on the choice of reaction conditions. Strong base, high temperature, and pressure favor the formation of diols whilst the opposite is true for the hydroxy esters.

SERINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

P(NMe2)3-Mediated Umpolung Alkylation and Nonylidic Olefination of α-Keto Esters

A commercial phosphorus-based reagent (P(NMe2)3) mediates umpolung alkylation of methyl aroylformates with benzylic and allylic bromides, leading to either Barbier-type addition or ylide-free olefination products upon workup. The reaction sequence is initiated by a two-electron redox addition of the tricoordinate phosphorus reagent with an α-keto ester compound (Kukhtin-Ramirez addition). A mechanistic rationale is offered for the chemoselectivity upon which the success of this nonmetal mediated C-C bond forming strategy is based.

Kinetic resolution of mandelate esters via stereoselective acylation catalyzed by lipase PS-30

By using lipase PS-30 as catalyst, the kinetic resolution of a series of racemic mandelate esters has been achieved via stereoselective acylation. The value of kinetic enantiomeric ratio (E) reached up to 197.5. Substituent effect is briefly discussed.