15833-61-1

Basic information

• Product Name: TETRAHYDRO-3-FURANMETHANOL
• Synonyms: Tetrahydro-3-furanylmethanol;(TETRAHYDROFURAN-3-YL)METHANOL;TETRAHYDRO-3-FURANMETHANOL;RARECHEM AL BD 0888;3-Hydroxymethyltetrahydrofuran;3-Hydroxymethyl-THF;Tetrahydrofuran-3-ylmetha...;(3-Oxolanyl)Methanol
• CAS NO: 15833-61-1
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.1317
• EINECS: 1806241-263-5
• Product Categories: API intermediates;Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 15833-61-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 76-77 °C4 mm Hg(lit.)
• Flash Point: 208 °F
• Appearance: /
• Density: 1.061 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0899mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: TETRAHYDRO-3-FURANMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-3-FURANMETHANOL(15833-61-1)
• EPA Substance Registry System: TETRAHYDRO-3-FURANMETHANOL(15833-61-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 15833-61-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless viscous liquid

General Description

Tetrahydro-3-furanmethanol was the main product formed during hydrolysis of 1,3-dioxolane compounds.

InChI:InChI=1/C5H10O2/c6-3-5-1-2-7-4-5/h5-6H,1-4H2

Upstream product

• 65805-36-9 3-(2-iodoethoxy)prop-1-ene 
• 79710-86-4 tetrahydrofuran-3-carboxaldehyde 
• 63972-17-8 1,3-diethyl 2-(2-hydroxyethyl)propanedioate 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 18132-98-4 α-hydroxymethyl-γ-butyrolactone 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 109-99-9 tetrahydrofuran 
• 67-56-1 methanol 
• 4360-91-2 α-carboxy-γ-butyrolactone 
• 1191-99-7 2,3-dihydro-2H-furan 
• 201230-82-2 carbon monoxide 
• 1708-29-8 2,5-dihydrofuran 
• 67-63-0 isopropyl alcohol 
• 488-93-7 3-Furoic acid 

Downstream Products

• 13423-15-9 3-methyltetrahydrofuran 
• 64190-48-3 dihydro-4-methyl-2(3H)-furanone 
• 1679-47-6 3-methyltetrahydro-2-furanone 
• 165253-29-2 3-(bromomethyl)oxolane 
• 1285528-65-5 3-[5-chloro-2-(tetrahydro-furan-3-ylmethoxy)-phenoxy]-azetidine-1-carboxylic acid tert-butyl ester 
• 1365033-53-9 methyl 4-fluoro-2-(tetrahydrofuran-3-ylmethoxy)benzoate 
• 1607822-72-9 3-((2-(trifluoromethoxy)phenoxy)methyl)tetrahydrofuran 
• 1574394-65-2 2-amino-6-oxo-4-(4-(tetrahydrofuran-3-yl)methoxy-3-(trifluoromethoxy)phenyl)-1,6-dihydropyrimidine-5-carbonitrile 
• 1574394-76-5 4-((tetrahydrofuran-3-yl)methoxy)-3-(trifluoromethoxy)benzaldehyde 
• 165253-31-6 (tetrahydro-3-furanyl)methylamine 
• 15833-63-3 (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 
• 89364-31-8 3-tetrahydrofuroic acid 
• 127047-77-2 4-acetoxy-3-(acetoxymethyl)-1-iodobutane 
• 96-47-9 2-methyltetrahydrofuran 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Production technology for 3-hydroxymethyltetrahydrofuran

The invention discloses a production technology for 3-hydroxymethyltetrahydrofuran, and belongs to the field of pesticide intermediate synthetic processes. The production technology is capable of using 2-butene-1,4-diol as a starting raw material, and synthesizing the 3-hydroxymethyltetrahydrofuran through a three-step reaction of dehydration cyclization, hydroformylation and reduction. The production technology is moderate in reaction conditions, low in cost, less in three wastes, and suitable for the industrial production.

Preparation method of tetrahydro-3-furanmethanol

The invention relates to the field of preparation of insecticides, in particular to a preparation method of tetrahydro-3-furanmethanol. The method comprises the steps as follows: 13.6 g of sodium ethoxide and 0.5 g of sodium iodide are dissolved in 120 mL of absolute ethyl alcohol, 32 g of diethyl malonate is dropwise added in an ice-water bath, the temperature is controlled at 20 DEG C or below,stirring is performed continuously for 1 h after addition, then 30.3 g of ethyl bromoacetate is slowly added, the temperature is increased to 50-60 DEG C after addition, stirring is performed for about 8 h, ethyl bromoacetate is detected to be used up through gas chromatography, a heating reaction is stopped, the system is cooled to the room temperature, 10 mL of a saturated ammonium chloride solution is added with stirring, the system is adjusted to be neutral or slightly acid, solvent ethyl alcohol is evaporated, residues are dissolved in 100 mL of water and 100 mL of ethyl acetate for extraction, solution separation is performed, an organic phase is separated, the solvent ethyl acetate is removed from the organic phase, reduced pressure distillation is performed through an oil pump, andthe first fraction point, namely, a triethyl 1,1,2-ethanetricarboxylate product, is collected. The process is simple, safety in actual production is guaranteed, and the product with higher yield is obtained.