26772-93-0

Basic information

• Product Name: 4-CHLORO-N-METHYLFORMANILIDE
• Synonyms: 4'-CHLORO-N-METHYLFORMANILIDE;4-CHLORO-N-METHYLFORMANILIDE;4-CHLORO-N-FORMYL-N-METHYLANILINE;Chloromethylformanilide;N-(4-Chlorophenyl)-N-methylformamide;4-CHLORO-N-METHYLFORMANILIDE 98+%;4-Chlorophenyl(methyl)formamide;4'-Chloro-N-methylformanilide
• CAS NO: 26772-93-0
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• Mol File: 26772-93-0.mol
• Article Data: 55

Chemical Properties

• Melting Point: 52 °C
• Boiling Point: 166 °C / 20mmHg
• Flash Point: 133.7°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.00135mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• PKA: -0.25±0.50(Predicted)
• CAS DataBase Reference: 4-CHLORO-N-METHYLFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-METHYLFORMANILIDE(26772-93-0)
• EPA Substance Registry System: 4-CHLORO-N-METHYLFORMANILIDE(26772-93-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 26772-93-0(Hazardous Substances Data)

Usage

General Description

4-CHLORO-N-METHYLFORMANILIDE is a chemical compound used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a chlorinated derivative of N-methylformanilide, and its primary function is as a building block in the production of various active ingredients. The compound is also used in the production of dyes and pigments. It is classified as a hazardous substance and can cause irritation to the skin, eyes, and respiratory system if not handled properly. Additionally, it may have harmful effects on aquatic organisms if released into the environment. Therefore, proper precautions should be taken when working with and disposing of this chemical.

InChI:InChI=1/C8H8ClNO/c1-10(6-11)8-4-2-7(9)3-5-8/h2-6H,1H3

Upstream product

• 123-39-7 N-Methylformamide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 124-38-9 carbon dioxide 
• 932-96-7 N-methyl(p-chloroaniline) 
• 109-94-4 formic acid ethyl ester 
• 106-47-8 4-chloro-aniline 
• 64-18-6 formic acid 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 74-88-4 methyl iodide 
• 15249-31-7 N-phenyl-N-methyl-2-propynamide 
• 298-12-4 Glyoxilic acid 
• 698-69-1 4-chloro-N,N-dimethylaniline 
• 1314108-49-0 2-((4-chlorophenyl)(methyl)amino)-1-(4-methoxyphenyl)ethanone 
• 14064-16-5 <4-(Dimethylamino)phenyl>trimethylstannan 

Downstream Products

• 698-69-1 4-chloro-N,N-dimethylaniline 
• 67-56-1 methanol 
• 932-96-7 N-methyl(p-chloroaniline) 
• 208177-33-7 (4-Chloro-phenyl)-(2,7-dichloro-10-methyl-10H-indolo[3,2-b]quinolin-11-yl)-methyl-amine 
• 208177-08-6 (E)-1,2-Dichloro-N,N'-bis-(4-chloro-phenyl)-N,N'-dimethyl-ethene-1,2-diamine 
• 60434-13-1 5-chloro-1-methylindoline-2, 3-dione 
• 653605-06-2 8,8'-bis(5,11-dimethyl-5,6,11,12-tetrahydro-2-chlorodibenzo[b,f][1,5]diazocine) 
• 208176-50-5 N-(4-chlorophenyl)-N-cyclopropylmethylamine 
• 180140-06-1 (E)-1,2-Dichloro-N,N'-bis-(4-chloro-phenyl)-N,N'-dimethyl-ethene-1,2-diamine 
• 535920-91-3 7-chloro-4-(4-chlorophenyl)-1-methylbenzo[f][1,4]-diazepine-2,3-dicarboxylic anhydride 
• 764-93-2 1-decyne 

Relevant articles and documents

Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

Ionization of Porous Hypercrosslinked Polymers for Catalyzing Room-Temperature CO2 Reduction via Formamides Synthesis

Porous materials with heterogeneous nature occupy a pivotal position in the chemical industry. This work described a facile pre- and post-synthetic approach to modify porous hypercrosslinked polymer with quaternary ammonium bromide, rendering it as efficient catalyst for CO2 conversion. The as-prepared porous ionic polymer (PiP@QA) displayed an improved specific surface area of 301 m2·g?1 with hierarchically porous structure, good selective adsorption of CO2, as well as high ion density. Accordingly, PiP@QA catalyst exhibited excellent catalytic performances for the solvent-free synthesis of various formamides from CO2, amines and phenylsilane under 35?°C and 0.5?MPa. We speculated that the superior catalytic efficiency and broad substrate scope of this catalyst could be resulted from the synergistic effect of flexible ionic sites with unique nanoporous channel that might increase the collision probability of reactants and active sites as well as enhance the diffusion of reactants and products during the reaction process. With the good reusability, PiP@QA was also available for the efficient conversion of simulated flue gas (15% CO2 in N2, v/v) into target formamides with quantitative selectivity at room temperature, which further highlighted its industrial application potential in chemical recycling the real-word CO2 to valuable products. Graphic Abstract: [Figure not available: see fulltext.].

Ligand-Enabled Ni-Al Bimetallic Catalysis for Nonchelated Dual C-H Annulation of Arylformamides and Alkynes

A bifunctional secondary phosphine oxide (SPO) ligand-controlled method was developed for Ni-Al-catalyzed nonchelated dual C-H annulation of arylformamides with alkynes, providing a series of substituted amide-containing heterocycles in ≤97% yield. The SPO-bound bimetallic catalysis proved to be critical to the reaction efficiency.