54683-91-9

Upstream product

• 95-57-8 2-monochlorophenol 
• 98-88-4 benzoyl chloride 
• 93-99-2 benzoic acid phenyl ester 
• 614-45-9 tert-Butyl peroxybenzoate 
• 108-90-7 chlorobenzene 
• 7553-56-2 iodine 
• 94-36-0 dibenzoyl peroxide 
• 7446-70-0 aluminium trichloride 
• 630-20-6 1,1,1,2-tetrachoroethane 
• 98-07-7 Benzotrichlorid 
• 100-52-7 benzaldehyde 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 65-85-0 benzoic acid 
• 129103-70-4 2-iodophenyl benzoate 

Downstream Products

• 35582-86-6 (3-chloro-2-hydroxyphenyl)(phenyl)methanone 
• 55191-20-3 (3-chloro-4-hydroxyphenyl)(phenyl)methanone 
• 95-57-8 2-monochlorophenol 
• 65-85-0 benzoic acid 
• 179019-00-2 [3-chloro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-phenyl-methanol 
• 179018-56-5 [3-chloro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-phenyl-methanone 
• 404947-48-4 (4-allylhepta-1,6-dien-4-yl) benzene 

Relevant academic research and scientific papers

Synthesis, biological evaluation and molecular dynamics studies of oxadiazine derivatives as potential anti-hepatotoxic agents

Generally, herbal medicines having remarkable popularity for treating liver ailments, but they are still unacceptable because of the deprivation of herbal drug standardization. Therefore, there is a need for promising synthetic drugs to overcome the criti

Method for preparing diaryl ester compound through efficient catalysis of pyridine palladium

The invention discloses a method for preparing a diaryl ester compound through efficient catalysis of pyridine palladium. The method is used for high-efficiency high-yield preparation of the diaryl ester compound under mild conditions by taking a phenol compound, an iodobenzene compound and carbon monoxide as raw materials, triethylamine as alkali and pyridine palladium as a catalyst. The method provided by the invention has the advantages of less usage amount of the palladium catalyst, high catalytic activity of the palladium catalyst, stability of the palladium catalyst to air, simple operation, short reaction time and high atom economy, opens up a low-cost, green and efficient way for preparation of diaryl ester compounds, and has broad application prospects.

Nickel-Catalyzed Cross-Coupling of Aryl Redoxactive Esters with Aryl Zinc Reagents

A nickel-catalyzed aryl-aroyloxyl C(sp2)-O radical cross-coupling reaction conducted using a redox active ester with aryl zinc reagent was developed. This method demonstrates a new disconnection approach for formation of aryl aryl esters. In the one-pot sequential process, the readily available aryl carboxylic acids can be converted into functionalized aryl aryl esters and heteroaryl esters. This protocol is amenable to the gram-scale synthesis. The present method has a wide substrate scope and high functional group tolerance.

Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing

In chemical synthesis, rapid intramolecular rearrangements often foil attempts at site-selective bimolecular functionalization.We developed a microfluidic technique that outpaces the very rapid anionic Fries rearrangement to chemoselectively functionalize iodophenyl carbamates at the ortho position. Central to the technique is a chip microreactor of our design, which can deliver a reaction time in the submillisecond range even at cryogenic temperatures.The microreactorwas applied to the synthesis of afesal, a bioactive molecule exhibiting anthelmintic activity, to demonstrate its potential for practical synthesis and production.

Solid-Phase Benzoylation of Phenols and Alcohols in Microwave Reactor: An Ecofriendly Protocol

An efficient solid-phase benzoylation of phenols and alcohols was developed under microwave irradiation. A stoichiometric amount of benzoyl chloride was sufficient to carry out the reaction. This benzoylation features short reaction time, good yields, and easy workup procedures. Furthermore, the scope of the reaction was extended to prepare 3,5-dinitrobenzoyl derivatives of alcohols.

Metal-free synthesis of aryl esters by coupling aryl carboxylic acids and aryl boronic acids

A facile synthesis of aryl esters is developed by coupling aryl carboxylic acids and aryl boronic acids in the presence of PhI(OAc)2 and carbonyl diimidazole. A wide range of functional groups were tolerant to the metal-free reaction condition that led to the desired products in good yields.

Montmorillonite K10 and KSF clays as acidic and green catalysts for effective esterification of phenols and alcohols under MWI

Montmorillonite K-10 and KSF clays catalyze esterification of phenols and alcohols under microwave irradiation and solvent-free conditions in high yields within seconds.

Ruthenium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols

An efficient methodology to access benzoate derivatives via tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols catalyzed by ruthenium/NHC was developed. This operationally simple one-pot process uses O2 as the clean oxidant, producing esters in good to excellent yields.

Palladium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols

A palladium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols to access aryl benzoate derivatives is described. The procedure tolerates a series of functional groups, such as methoxy, nitro, cyano, chloro, fluoro and bromo groups. Thus, it represents a practically alternative method to access aryl benzoate derivatives.

Palladium/NHC-catalyzed oxidative esterification of aldehydes with phenols

A palladium-catalyzed oxidative esterification of aldehydes with phenols is described, using air as the clean oxidant. This reaction tolerates many functional groups, providing esters with yields ranging from moderate to excellent.