621-76-1 Usage
Chemical Properties
clear colorless liquid
Uses
Different sources of media describe the Uses of 621-76-1 differently. You can refer to the following data:
1. Tripropoxymethane can be used in the lipase-?catalyzed esterification aimed at the kinetic resolution of racemic acids, circumventing the adverse effects of the water formed in the course of the reaction.
2. Tripropyl orthoformate was used as alcohol donor to investigate the activity and enantioselectivity of Novozym 435 in the esterification of rac-fenoprofen in methylcyclohexane. It may be used as a drying agent during the synthesis of squaraine derivatives.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 3801, 1955 DOI: 10.1021/ja01619a036
General Description
Gas phase reactions of the rare earth metal cations with tripropyl orthoformate were studied by Fourier transform ion cyclotron resonance mass spectrometry.
Check Digit Verification of cas no
The CAS Registry Mumber 621-76-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 621-76:
(5*6)+(4*2)+(3*1)+(2*7)+(1*6)=61
61 % 10 = 1
So 621-76-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H22O3/c1-4-7-11-10(12-8-5-2)13-9-6-3/h10H,4-9H2,1-3H3
621-76-1Relevant articles and documents
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Alexander,Busch
, p. 554 (1952)
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Synthesis and Application of α,ω-Bis(dialkylamino)oligooxaalkanes and Their Analogs as Phase-Transfer Catalysts in Heterogeneous Synthesis of Trialkyl Orthoformates
Shtamburg, V. G.,Skobelev, O. L.,Grinev, V. M.,Dmitrienko, A. D.,Pleshkova, A. P.,Pritykin, L. M.
, p. 609 - 612 (2007/10/03)
α,ω-Bis(dialkylamino)oligooxaalkanes, 1,8-bis(alkoxyamino)-3,6-dioxaoctanes, and 1,8-bis(diethylamino)-3,6-dioxaoctane N,N'-dioxide are efficient phase-transfer catalysts, the use of which ensures preparation in high yields of trialkyl orthoformates from chloroform and primary alcohols in the heterogeneous systems CH2Cl2-solid alkali metal hydroxide.
On the Mechanism of Acetalization Reactions with Carboxamide-Dialkyl Sulfate Adducts; a New Method of Preparation of Orthocarboxylic Esters and of Cleavage of Carboxamides.
Kantlehner, Willi,Gutbrod, Heinz-Dieter
, p. 1677 - 1688 (2007/10/02)
It is shown that the efficiency of carboxamide-dialkyl-sulfate adducts in acetalization reactions depends on their alkylation ability.A mechanism of acetal formation using orthoformates as acetalization reagents is proposed.Alcoholysis of carboxamide-dialkyl sulfate adducts 1b, 11, 13 affords orthocarboxylic esters.Carboxamides and carboxmorpholides react with dimethyl sulfate/methanol to give methyl esters.
