7370-58-3Relevant articles and documents
Selenosulfides Tethered to gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H2S Probe Development
Suarez, S. Israel,Ambrose, Rynne,Kalk, Madison A.,Lukesh, John C.
, p. 15736 - 15740 (2019)
Selenosulfides coupled to gem-dimethyl esters provide an exceptional platform for H2S probe development. With the sulfur half being nonessential to its high reactivity and selectivity towards H2S, we highlight the unique flexibility of our design by improving its biocompatibility and tissue specificity through structural modifications of its sulfide moiety.
Fabrication of redox-responsive Bi(mPEG-PLGA)-Se2 micelles for doxorubicin delivery
Birhan, Yihenew Simegniew,Hailemeskel, Balkew Zewge,Mekonnen, Tefera Worku,Hanurry, Endiries Yibru,Darge, Haile Fentahun,Andrgie, Abegaz Tizazu,Chou, Hsiao-Ying,Lai, Juin-Yih,Hsiue, Ging-Ho,Tsai, Hsieh-Chih
, (2019)
Stimuli-responsive polymeric nanostructures have emerged as potential drug carriers for cancer therapy. Herein, we synthesized redox-responsive diselenide bond containing amphiphilic polymer, Bi(mPEG-PLGA)-Se2 from mPEG-PLGA and 3,3′-diselanediyldipropanoic acid (DSeDPA) using DCC/DMAP as coupling agents. Due to its amphiphilic nature, Bi(mPEG-PLGA)-Se2 self-assembled in to stable micelles in aqueous solution with a hydrodynamic size of 123.9 ± 0.85 nm. The Bi(mPEG-PLGA)-Se2 micelles exhibited DOX-loading content (DLC) of 6.61 wt% and encapsulation efficiency (EE) of 54.9%. The DOX-loaded Bi(mPEG-PLGA)-Se2 micelles released 73.94% and 69.54% of their cargo within 72 h upon treatment with 6 mM GSH and 0.1% H2O2, respectively, at pH 7.4 and 37 °C. The MTT assay results demonstrated that Bi(mPEG-PLGA)-Se2 was devoid of any inherent toxicity and the DOX-loaded micelles showed pronounced antitumor activities against HeLa cells, 44.46% of cells were viable at maximum dose of 7.5 μg/mL. The cellular uptake experiment further confirmed the internalization of DOX-loaded Bi(mPEG-PLGA)-Se2 micelles and endowed redox stimuli triggered drug release in cytosol and nuclei of cancer cells. Overall, the results suggested that the smart, biocompatible Bi(mPEG-PLGA)-Se2 copolymer could serve as potential drug delivery biomaterial for the controlled release of hydrophobic drugs in cancer cells.
Synthesis of functionalized organoselenium materials: Selenides and diselenides containing cholesterol
Frizon, Tiago E.,Rafique, Jamal,Saba, Sumbal,Bechtold, Ivan H.,Gallardo, Hugo,Braga, Antonio L.
supporting information, p. 3470 - 3476 (2015/06/08)
Abstract A simple and efficient procedure for the synthesis of three new series of chalcogen liquid crystals, based on selenides and diselenides, containing cholesterol in their structure, is described. Thermal and liquid crystalline properties were investigated by POM, DSC, TGA and XRD scattering. Six of the nine molecules synthesized showed liquid crystal properties, with smectic mesomorphism. All the compounds presented good thermal stability. The smectic mesomorphism was confirmed through XRD analysis. The morphology of the surface of the films was investigated by using atomic force microscopy (AFM). All prepared diselenides showed good glutathione peroxidase like activity and one of the diselenides was 3.3 times more active than the standard Ebselen.