Interactions between BACE1 (green) and compound 17g (yellow) rendered as a surface view (A), in 3D (B), and 2D (C)

June 12, 2024

• Title:       

  Interactions between BACE1 (green) and compound 17g (yellow) rendered as a surface view (A), in 3D (B), and 2D (C)

• Image Source:

  Acyl guanidine inhibitors of β-secretase (bACE-1): Optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis

• Mark:

  Figure 4

• Associated context:

  The structure also reveals a total of 18 protein−ligand interactions encompassing nearly every heavy atom of 17g and highlighting the high ligand efficiency for the series (Figure 4).