Explore the possible mechanism of this catalytic silylation reaction

June 14, 2024

• Title:       

  Explore the possible mechanism of this catalytic silylation reaction

• Image Source:

  Palladium-catalyzed silylation reaction between benzylic halides and silylboronate

• Mark:

  3,4

• Associated context:

  After the successful synthesis of various benzyl silane compounds, we next turned our attention to exploring the possible mechanism of this catalytic silylation reaction. An enantioenriched 2-(chloro(phenyl)methyl)naphthalene was prepared and subjected to this coupling reaction. It was found that the desired silylation product 4 could be obtained in 67% yield and with retention of substrate's enantiopurity.