Alkylation of 3 was performed by heating with K2CO3 and prenyl bromide

July 04, 2024

• Title:       

  Alkylation of 3 was performed by heating with K2CO3 and prenyl bromide 

• Image Source:

  Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols

• Mark:

  Scheme 1

• Associated context:

  As shown in  Scheme 1, alkylation of 3 was performed by heating with K₂CO₃ (CAS 584-08-7) and prenyl bromide in DMF at 60 °C to give the natural product 2,  which underwent Claisen rearrangement when heated at 150 °C  in the presence of N-methyl 2-pyrolidone (NMP) to form buchapine  (1) in 40% yield.