The new macrocyclic molecule 19 shows dramatically improved solubility in methanol

July 05, 2024

• Title:       

  The new macrocyclic molecule 19 shows dramatically improved solubility in methanol 

• Image Source:

  A general and high yielding fragment coupling synthesis of heteroatom-bridged calixarenes and the unprecedented examples of calixarene cavity fine-tuned by bridging heteroatoms

• Mark:

  Scheme 5

• Associated context:

  In the presence of diisopropylethylamine, for example, diazadioxocalix[2]arene[2]triazine 9 underwent an efficient nucleophilic substitution reaction with diethanolamine to furnish product 19 in 72% yield. Having been functionalized with four hydroxy groups, the new macrocyclic molecule 19 shows dramatically improved solubility in methanol (Scheme 5).